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Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study
Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731530/ https://www.ncbi.nlm.nih.gov/pubmed/33335938 http://dx.doi.org/10.1093/ofid/ofaa538 |
| _version_ | 1783621917526196224 |
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| author | Liu, Jiajun Tong, Steven Y C Davis, Joshua S Rhodes, Nathaniel J Scheetz, Marc H |
| author_facet | Liu, Jiajun Tong, Steven Y C Davis, Joshua S Rhodes, Nathaniel J Scheetz, Marc H |
| author_sort | Liu, Jiajun |
| collection | PubMed |
| description | Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt. |
| format | Online Article Text |
| id | pubmed-7731530 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77315302020-12-16 Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study Liu, Jiajun Tong, Steven Y C Davis, Joshua S Rhodes, Nathaniel J Scheetz, Marc H Open Forum Infect Dis Brief Reports Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt. Oxford University Press 2020-11-04 /pmc/articles/PMC7731530/ /pubmed/33335938 http://dx.doi.org/10.1093/ofid/ofaa538 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Reports Liu, Jiajun Tong, Steven Y C Davis, Joshua S Rhodes, Nathaniel J Scheetz, Marc H Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title | Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title_full | Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title_fullStr | Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title_full_unstemmed | Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title_short | Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study |
| title_sort | vancomycin exposure and acute kidney injury outcome: a snapshot from the camera2 study |
| topic | Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731530/ https://www.ncbi.nlm.nih.gov/pubmed/33335938 http://dx.doi.org/10.1093/ofid/ofaa538 |
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