In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

BACKGROUND: Overexpression of c-Myc is required for the progression of pre-malignant plasma cells in monoclonal gammopathy of undetermined significance (MGUS) to malignant plasma cells in multiple myeloma (MM). c-Myc also increases glutamine anaplerosis into the tricarboxylic acid (TCA) cycle within...

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Detalles Bibliográficos
Autores principales: Gonsalves, Wilson I., Jang, Jin Sung, Jessen, Erik, Hitosugi, Taro, Evans, Laura A., Jevremovic, Dragan, Pettersson, Xuan-Mai, Bush, Alexander Graham, Gransee, Jaimee, Anderson, Emilie I., Kumar, Shaji K., Nair, K. Sreekumaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731537/
https://www.ncbi.nlm.nih.gov/pubmed/33308307
http://dx.doi.org/10.1186/s40170-020-00235-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731537/
https://www.ncbi.nlm.nih.gov/pubmed/33308307
http://dx.doi.org/10.1186/s40170-020-00235-4

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