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Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia

The purpose of this article was to present a case of successful long term treatment with azacitidine in patient with Chronic Myelomonocytic Leukemia (CMML) and discussing possible contributing factors for its long term efficacy. Data from our case were compared with similar data available in the lit...

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Autores principales: Čemažar, Luka, Podgornik, Helena, Šimec, Njetočka Gredelj, Zver, Samo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731662/
https://www.ncbi.nlm.nih.gov/pubmed/33324479
http://dx.doi.org/10.4081/hr.2020.8537
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author Čemažar, Luka
Podgornik, Helena
Šimec, Njetočka Gredelj
Zver, Samo
author_facet Čemažar, Luka
Podgornik, Helena
Šimec, Njetočka Gredelj
Zver, Samo
author_sort Čemažar, Luka
collection PubMed
description The purpose of this article was to present a case of successful long term treatment with azacitidine in patient with Chronic Myelomonocytic Leukemia (CMML) and discussing possible contributing factors for its long term efficacy. Data from our case were compared with similar data available in the literature. Effective treatment with azacitidine resulted in overall survival of 11 years 5 months and we showed that applying multiple cycles of treatment is feasible. Our patient received 71 cycles of treatment with total duration of 7 years and 3 months. Our report about a patient with CMML and a good clinical course revealed, that long term treatment with azacitidine is feasible in some patients. Initially low bone marrow blast count, a relatively small malignant CMML clone, reduction of spleen size and fast platelet response seemed to be factors determining long term response to treatment in our patient. More data on CMML treatment by Hypomethylating Agents and their analysis are needed in order to make firm conclusions.
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spelling pubmed-77316622020-12-14 Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia Čemažar, Luka Podgornik, Helena Šimec, Njetočka Gredelj Zver, Samo Hematol Rep Case Report The purpose of this article was to present a case of successful long term treatment with azacitidine in patient with Chronic Myelomonocytic Leukemia (CMML) and discussing possible contributing factors for its long term efficacy. Data from our case were compared with similar data available in the literature. Effective treatment with azacitidine resulted in overall survival of 11 years 5 months and we showed that applying multiple cycles of treatment is feasible. Our patient received 71 cycles of treatment with total duration of 7 years and 3 months. Our report about a patient with CMML and a good clinical course revealed, that long term treatment with azacitidine is feasible in some patients. Initially low bone marrow blast count, a relatively small malignant CMML clone, reduction of spleen size and fast platelet response seemed to be factors determining long term response to treatment in our patient. More data on CMML treatment by Hypomethylating Agents and their analysis are needed in order to make firm conclusions. PAGEPress Publications, Pavia, Italy 2020-12-02 /pmc/articles/PMC7731662/ /pubmed/33324479 http://dx.doi.org/10.4081/hr.2020.8537 Text en ©Copyright: the Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution NonCommercial 4.0 License (CC BY-NC 4.0).
spellingShingle Case Report
Čemažar, Luka
Podgornik, Helena
Šimec, Njetočka Gredelj
Zver, Samo
Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title_full Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title_fullStr Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title_full_unstemmed Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title_short Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
title_sort successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731662/
https://www.ncbi.nlm.nih.gov/pubmed/33324479
http://dx.doi.org/10.4081/hr.2020.8537
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