Membrane depolarization is required for pressure-dependent pulmonary arterial tone but not enhanced vasoconstriction to endothelin-1 following chronic hypoxia

Enhanced vasoconstriction is increasingly identified as an important contributor to the development of pulmonary hypertension. Chronic hypoxia results in enhanced Rho kinase mediated Ca(2+) sensitization contributing to pressure-dependent pulmonary arterial tone as well as augmented vasoconstriction...

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Detalles Bibliográficos
Autores principales: Norton, Charles E, Jernigan, Nikki L, Walker, Benjimen R, Resta, Thomas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731711/
https://www.ncbi.nlm.nih.gov/pubmed/33343882
http://dx.doi.org/10.1177/2045894020973559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731711/
https://www.ncbi.nlm.nih.gov/pubmed/33343882
http://dx.doi.org/10.1177/2045894020973559

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