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Cell-autonomous role of Presenilin in age-dependent survival of cortical interneurons
BACKGROUND: Mutations in the PSEN1 and PSEN2 genes are the major cause of familial Alzheimer’s disease. Previous studies demonstrated that Presenilin (PS), the catalytic subunit of γ-secretase, is required for survival of excitatory neurons in the cerebral cortex during aging. However, the role of P...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731773/ https://www.ncbi.nlm.nih.gov/pubmed/33302995 http://dx.doi.org/10.1186/s13024-020-00419-y |