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Helicobacter pylori healthy South Asians

We aimed to estimate the pooled prevalence of Helicobacter pylori among asymptomatic South Asians based on available literature and highlight the importance of screening asymptomatic individuals and implementing preventive strategies for eradicating H. pylori. Electronic databases such as PubMed and...

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Autores principales: Kharel, Sanjeev, Bist, Anil, Shrestha, Suraj, Homagain, Sushan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731813/
https://www.ncbi.nlm.nih.gov/pubmed/33319035
http://dx.doi.org/10.1002/jgh3.12426
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author Kharel, Sanjeev
Bist, Anil
Shrestha, Suraj
Homagain, Sushan
author_facet Kharel, Sanjeev
Bist, Anil
Shrestha, Suraj
Homagain, Sushan
author_sort Kharel, Sanjeev
collection PubMed
description We aimed to estimate the pooled prevalence of Helicobacter pylori among asymptomatic South Asians based on available literature and highlight the importance of screening asymptomatic individuals and implementing preventive strategies for eradicating H. pylori. Electronic databases such as PubMed and Embase, a regional database of WHO South Asian Region, and gray literature sites were searched for relevant studies from 1983 to 5 May 2020. In addition, references of the included studies were thoroughly searched. The random‐effect model was used to calculate the pooled prevalence with a 95% confidence interval (CI) along with subgroup analysis. Analysis of 19 studies showed a pooled prevalence of 56.5%, ranging from 10.3 to 91.7%. In subgroup analysis by country, the highest prevalence rate was reported from Bangladesh (86.3%, 95% CI: 0.806–0.921), whereas the lowest prevalence was from Sri Lanka (10.3%, 95% CI: 0.072–0.135). No differences were found between males and females. Prevalence among children and adolescents was 65.3% (95% CI: 0.529–0.777), greater than adults, 56.9% (95% CI: 0.353–0.785). The prevalence rate showed a decreasing trend upon comparison of studies conducted before and after 2000. Our analysis reveals the high prevalence of H. pylori infection among asymptomatic healthy populations in South Asia, particularly in children and adolescents. Public health awareness and sanitation interventions, pure drinking water, and respective strategies on a policy level to eradicate H. pylori and additional extensive multicentric cohort studies are necessary.
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spelling pubmed-77318132020-12-13 Helicobacter pylori healthy South Asians Kharel, Sanjeev Bist, Anil Shrestha, Suraj Homagain, Sushan JGH Open Review Articles We aimed to estimate the pooled prevalence of Helicobacter pylori among asymptomatic South Asians based on available literature and highlight the importance of screening asymptomatic individuals and implementing preventive strategies for eradicating H. pylori. Electronic databases such as PubMed and Embase, a regional database of WHO South Asian Region, and gray literature sites were searched for relevant studies from 1983 to 5 May 2020. In addition, references of the included studies were thoroughly searched. The random‐effect model was used to calculate the pooled prevalence with a 95% confidence interval (CI) along with subgroup analysis. Analysis of 19 studies showed a pooled prevalence of 56.5%, ranging from 10.3 to 91.7%. In subgroup analysis by country, the highest prevalence rate was reported from Bangladesh (86.3%, 95% CI: 0.806–0.921), whereas the lowest prevalence was from Sri Lanka (10.3%, 95% CI: 0.072–0.135). No differences were found between males and females. Prevalence among children and adolescents was 65.3% (95% CI: 0.529–0.777), greater than adults, 56.9% (95% CI: 0.353–0.785). The prevalence rate showed a decreasing trend upon comparison of studies conducted before and after 2000. Our analysis reveals the high prevalence of H. pylori infection among asymptomatic healthy populations in South Asia, particularly in children and adolescents. Public health awareness and sanitation interventions, pure drinking water, and respective strategies on a policy level to eradicate H. pylori and additional extensive multicentric cohort studies are necessary. Wiley Publishing Asia Pty Ltd 2020-10-12 /pmc/articles/PMC7731813/ /pubmed/33319035 http://dx.doi.org/10.1002/jgh3.12426 Text en © 2020 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Kharel, Sanjeev
Bist, Anil
Shrestha, Suraj
Homagain, Sushan
Helicobacter pylori healthy South Asians
title Helicobacter pylori healthy South Asians
title_full Helicobacter pylori healthy South Asians
title_fullStr Helicobacter pylori healthy South Asians
title_full_unstemmed Helicobacter pylori healthy South Asians
title_short Helicobacter pylori healthy South Asians
title_sort helicobacter pylori healthy south asians
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731813/
https://www.ncbi.nlm.nih.gov/pubmed/33319035
http://dx.doi.org/10.1002/jgh3.12426
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