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Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled c...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732056/ https://www.ncbi.nlm.nih.gov/pubmed/33306743 http://dx.doi.org/10.1371/journal.pone.0243942 |
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author | Chapman, Timothy J. Morris, Matthew C. Xu, Lei Pichichero, Michael E. |
author_facet | Chapman, Timothy J. Morris, Matthew C. Xu, Lei Pichichero, Michael E. |
author_sort | Chapman, Timothy J. |
collection | PubMed |
description | Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled cohort of 358 children we sought associations between physician-attended illness visits and bacterial colonization in the first five years of life. A subset of children was identified by unsupervised clustering analysis as infection and allergy prone (IAP). Several respiratory infection- and allergy-mediated illnesses co-occurred at higher rates in IAP children, while the rates of other illnesses were not significantly different between the groups. Analyses of nasopharyngeal (NP) pathobionts and microbiota commensals showed that early age of first colonization with pathobionts Streptococcus pneumonia, non-typeable Haemophilus influenzae, and Moraxella catarrhalis was associated with IAP children, and particularly Moraxella abundance was negatively associated with NP microbiome diversity. We conclude that mucosal pathobiont exposures in early life can influence susceptibility to respiratory illnesses in children. |
format | Online Article Text |
id | pubmed-7732056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77320562020-12-17 Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children Chapman, Timothy J. Morris, Matthew C. Xu, Lei Pichichero, Michael E. PLoS One Research Article Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled cohort of 358 children we sought associations between physician-attended illness visits and bacterial colonization in the first five years of life. A subset of children was identified by unsupervised clustering analysis as infection and allergy prone (IAP). Several respiratory infection- and allergy-mediated illnesses co-occurred at higher rates in IAP children, while the rates of other illnesses were not significantly different between the groups. Analyses of nasopharyngeal (NP) pathobionts and microbiota commensals showed that early age of first colonization with pathobionts Streptococcus pneumonia, non-typeable Haemophilus influenzae, and Moraxella catarrhalis was associated with IAP children, and particularly Moraxella abundance was negatively associated with NP microbiome diversity. We conclude that mucosal pathobiont exposures in early life can influence susceptibility to respiratory illnesses in children. Public Library of Science 2020-12-11 /pmc/articles/PMC7732056/ /pubmed/33306743 http://dx.doi.org/10.1371/journal.pone.0243942 Text en © 2020 Chapman et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Chapman, Timothy J. Morris, Matthew C. Xu, Lei Pichichero, Michael E. Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title | Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title_full | Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title_fullStr | Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title_full_unstemmed | Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title_short | Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
title_sort | nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732056/ https://www.ncbi.nlm.nih.gov/pubmed/33306743 http://dx.doi.org/10.1371/journal.pone.0243942 |
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