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Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children

Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled c...

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Autores principales: Chapman, Timothy J., Morris, Matthew C., Xu, Lei, Pichichero, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732056/
https://www.ncbi.nlm.nih.gov/pubmed/33306743
http://dx.doi.org/10.1371/journal.pone.0243942
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author Chapman, Timothy J.
Morris, Matthew C.
Xu, Lei
Pichichero, Michael E.
author_facet Chapman, Timothy J.
Morris, Matthew C.
Xu, Lei
Pichichero, Michael E.
author_sort Chapman, Timothy J.
collection PubMed
description Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled cohort of 358 children we sought associations between physician-attended illness visits and bacterial colonization in the first five years of life. A subset of children was identified by unsupervised clustering analysis as infection and allergy prone (IAP). Several respiratory infection- and allergy-mediated illnesses co-occurred at higher rates in IAP children, while the rates of other illnesses were not significantly different between the groups. Analyses of nasopharyngeal (NP) pathobionts and microbiota commensals showed that early age of first colonization with pathobionts Streptococcus pneumonia, non-typeable Haemophilus influenzae, and Moraxella catarrhalis was associated with IAP children, and particularly Moraxella abundance was negatively associated with NP microbiome diversity. We conclude that mucosal pathobiont exposures in early life can influence susceptibility to respiratory illnesses in children.
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spelling pubmed-77320562020-12-17 Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children Chapman, Timothy J. Morris, Matthew C. Xu, Lei Pichichero, Michael E. PLoS One Research Article Some children are more susceptible to viral and bacterial respiratory infections in the first few years of life than others. However, the factors contributing to this susceptibility are incompletely understood. In a retrospective analysis of clinical samples collected from a prospectively-enrolled cohort of 358 children we sought associations between physician-attended illness visits and bacterial colonization in the first five years of life. A subset of children was identified by unsupervised clustering analysis as infection and allergy prone (IAP). Several respiratory infection- and allergy-mediated illnesses co-occurred at higher rates in IAP children, while the rates of other illnesses were not significantly different between the groups. Analyses of nasopharyngeal (NP) pathobionts and microbiota commensals showed that early age of first colonization with pathobionts Streptococcus pneumonia, non-typeable Haemophilus influenzae, and Moraxella catarrhalis was associated with IAP children, and particularly Moraxella abundance was negatively associated with NP microbiome diversity. We conclude that mucosal pathobiont exposures in early life can influence susceptibility to respiratory illnesses in children. Public Library of Science 2020-12-11 /pmc/articles/PMC7732056/ /pubmed/33306743 http://dx.doi.org/10.1371/journal.pone.0243942 Text en © 2020 Chapman et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chapman, Timothy J.
Morris, Matthew C.
Xu, Lei
Pichichero, Michael E.
Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title_full Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title_fullStr Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title_full_unstemmed Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title_short Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
title_sort nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732056/
https://www.ncbi.nlm.nih.gov/pubmed/33306743
http://dx.doi.org/10.1371/journal.pone.0243942
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