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Interactions between Curcumin Derivatives and Amyloid-β Fibrils: Insights from Molecular Dynamics Simulations

[Image: see text] The aggregation of amyloid-β (Aβ) peptides into senile plaques is a hallmark of Alzheimer’s disease (AD) and is hypothesized to be the primary cause of AD related neurodegeneration. Previous studies have shown the ability of curcumin to both inhibit the aggregation of Aβ peptides i...

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Detalles Bibliográficos
Autores principales:	Jakubowski, Joseph M., Orr, Asuka A., Le, Doan A., Tamamis, Phanourios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732148/ https://www.ncbi.nlm.nih.gov/pubmed/31809572 http://dx.doi.org/10.1021/acs.jcim.9b00561

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