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Blockage of AEP attenuates TBI-induced tau hyperphosphorylation and cognitive impairments in rats

Traumatic brain injury (TBI) is regarded as a high-risk factor for Alzheimer's disease (AD). Asparaginyl endopeptidase (AEP), a lysosomal cysteine protease involved in AD pathogenesis, is normally activated under acidic conditions and also in TBI. However, both the molecular mechanism underlyin...

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Detalles Bibliográficos
Autores principales:	Liu, Yi, Guo, Cuiping, Ding, Yi, Long, Xiaobing, Li, Wensheng, Ke, Dan, Wang, Qun, Liu, Rong, Wang, Jian-Zhi, Zhang, Huaqiu, Wang, Xiaochuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732271/ https://www.ncbi.nlm.nih.gov/pubmed/33040048 http://dx.doi.org/10.18632/aging.103841

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