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Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study

The neurotrophic potential of SARS-CoV-2 virus is manifesting as various neurological disorders in the present pandemic. Nervous system involvement can be due to the direct action of the virus on the brain tissue or due to an indirect action through the activation of immune-mediated mechanisms. This...

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Autores principales: Kushwaha, Suman, Seth, Vaibhav, Bapat, Prateek, R, KiranGowda, Chaturvedi, Monali, Gupta, Renu, Bhattar, Sonali, Maheshwari, Siddharth, Anthony, Aldrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732434/
https://www.ncbi.nlm.nih.gov/pubmed/33329335
http://dx.doi.org/10.3389/fneur.2020.588879
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author Kushwaha, Suman
Seth, Vaibhav
Bapat, Prateek
R, KiranGowda
Chaturvedi, Monali
Gupta, Renu
Bhattar, Sonali
Maheshwari, Siddharth
Anthony, Aldrin
author_facet Kushwaha, Suman
Seth, Vaibhav
Bapat, Prateek
R, KiranGowda
Chaturvedi, Monali
Gupta, Renu
Bhattar, Sonali
Maheshwari, Siddharth
Anthony, Aldrin
author_sort Kushwaha, Suman
collection PubMed
description The neurotrophic potential of SARS-CoV-2 virus is manifesting as various neurological disorders in the present pandemic. Nervous system involvement can be due to the direct action of the virus on the brain tissue or due to an indirect action through the activation of immune-mediated mechanisms. This study will discuss the detailed systematically evaluated clinical profile and relevant investigations and outcome of 14 laboratory confirmed SARS-CoV-2 positive patients presenting with neurological signs and symptoms. The patients were further categorized into confirmed, probable, and possible neurological associations. The probable association was found in meningoencephalitis (n = 4), stroke (n = 2), Guillain-Barré syndrome (n = 1), and anosmia (n = 1). The other six patients had coexisting neurological diseases with SARS-CoV-2. One patient with a large artery stroke succumbed to the illness due to respiratory complication. Memory impairment as a sequela is present during follow up of one encephalitis patient. Presently the early recognition and diagnosis of neurological manifestations remains a challenge for clinicians as the SARS-CoV-2 related neurological manifestations are in evolution. A long-term correlation study of clinical profile, radiological and laboratory investigations, along with neuropathological studies is needed to further understand the pathophysiology behind the SARS-CoV-2 neurological manifestations. Further understanding will facilitate timely recognition, therapeutic intervention, and possible prevention of long-term sequalae.
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spelling pubmed-77324342020-12-15 Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study Kushwaha, Suman Seth, Vaibhav Bapat, Prateek R, KiranGowda Chaturvedi, Monali Gupta, Renu Bhattar, Sonali Maheshwari, Siddharth Anthony, Aldrin Front Neurol Neurology The neurotrophic potential of SARS-CoV-2 virus is manifesting as various neurological disorders in the present pandemic. Nervous system involvement can be due to the direct action of the virus on the brain tissue or due to an indirect action through the activation of immune-mediated mechanisms. This study will discuss the detailed systematically evaluated clinical profile and relevant investigations and outcome of 14 laboratory confirmed SARS-CoV-2 positive patients presenting with neurological signs and symptoms. The patients were further categorized into confirmed, probable, and possible neurological associations. The probable association was found in meningoencephalitis (n = 4), stroke (n = 2), Guillain-Barré syndrome (n = 1), and anosmia (n = 1). The other six patients had coexisting neurological diseases with SARS-CoV-2. One patient with a large artery stroke succumbed to the illness due to respiratory complication. Memory impairment as a sequela is present during follow up of one encephalitis patient. Presently the early recognition and diagnosis of neurological manifestations remains a challenge for clinicians as the SARS-CoV-2 related neurological manifestations are in evolution. A long-term correlation study of clinical profile, radiological and laboratory investigations, along with neuropathological studies is needed to further understand the pathophysiology behind the SARS-CoV-2 neurological manifestations. Further understanding will facilitate timely recognition, therapeutic intervention, and possible prevention of long-term sequalae. Frontiers Media S.A. 2020-11-24 /pmc/articles/PMC7732434/ /pubmed/33329335 http://dx.doi.org/10.3389/fneur.2020.588879 Text en Copyright © 2020 Kushwaha, Seth, Bapat, R, Chaturvedi, Gupta, Bhattar, Maheshwari and Anthony. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Kushwaha, Suman
Seth, Vaibhav
Bapat, Prateek
R, KiranGowda
Chaturvedi, Monali
Gupta, Renu
Bhattar, Sonali
Maheshwari, Siddharth
Anthony, Aldrin
Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title_full Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title_fullStr Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title_full_unstemmed Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title_short Neurological Associations of COVID-19—Do We Know Enough: A Tertiary Care Hospital Based Study
title_sort neurological associations of covid-19—do we know enough: a tertiary care hospital based study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732434/
https://www.ncbi.nlm.nih.gov/pubmed/33329335
http://dx.doi.org/10.3389/fneur.2020.588879
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