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Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report

In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gen...

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Autores principales: Cenciarelli, Sabina, Calbi, Valeria, Barzaghi, Federica, Bernardo, Maria Ester, Oltolini, Chiara, Migliavacca, Maddalena, Gallo, Vera, Tucci, Francesca, Fraschetta, Federico, Albertazzi, Elena, Fratini, Elena Sophia, Consiglieri, Giulia, Giannelli, Stefania, Dionisio, Francesca, Sartirana, Claudia, Racca, Sara, Camesasca, Chiara, Peretto, Giovanni, Daverio, Rita, Esposito, Antonio, De Cobelli, Francesco, Silvani, Paolo, Rabusin, Marco, Cara, Andrea, Trabattoni, Daria, Dispinseri, Stefania, Scarlatti, Gabriella, Piemonti, Lorenzo, Lampasona, Vito, Cicalese, Maria Pia, Aiuti, Alessandro, Ferrua, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732473/
https://www.ncbi.nlm.nih.gov/pubmed/33329599
http://dx.doi.org/10.3389/fimmu.2020.603428
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author Cenciarelli, Sabina
Calbi, Valeria
Barzaghi, Federica
Bernardo, Maria Ester
Oltolini, Chiara
Migliavacca, Maddalena
Gallo, Vera
Tucci, Francesca
Fraschetta, Federico
Albertazzi, Elena
Fratini, Elena Sophia
Consiglieri, Giulia
Giannelli, Stefania
Dionisio, Francesca
Sartirana, Claudia
Racca, Sara
Camesasca, Chiara
Peretto, Giovanni
Daverio, Rita
Esposito, Antonio
De Cobelli, Francesco
Silvani, Paolo
Rabusin, Marco
Cara, Andrea
Trabattoni, Daria
Dispinseri, Stefania
Scarlatti, Gabriella
Piemonti, Lorenzo
Lampasona, Vito
Cicalese, Maria Pia
Aiuti, Alessandro
Ferrua, Francesca
author_facet Cenciarelli, Sabina
Calbi, Valeria
Barzaghi, Federica
Bernardo, Maria Ester
Oltolini, Chiara
Migliavacca, Maddalena
Gallo, Vera
Tucci, Francesca
Fraschetta, Federico
Albertazzi, Elena
Fratini, Elena Sophia
Consiglieri, Giulia
Giannelli, Stefania
Dionisio, Francesca
Sartirana, Claudia
Racca, Sara
Camesasca, Chiara
Peretto, Giovanni
Daverio, Rita
Esposito, Antonio
De Cobelli, Francesco
Silvani, Paolo
Rabusin, Marco
Cara, Andrea
Trabattoni, Daria
Dispinseri, Stefania
Scarlatti, Gabriella
Piemonti, Lorenzo
Lampasona, Vito
Cicalese, Maria Pia
Aiuti, Alessandro
Ferrua, Francesca
author_sort Cenciarelli, Sabina
collection PubMed
description In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
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spelling pubmed-77324732020-12-15 Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report Cenciarelli, Sabina Calbi, Valeria Barzaghi, Federica Bernardo, Maria Ester Oltolini, Chiara Migliavacca, Maddalena Gallo, Vera Tucci, Francesca Fraschetta, Federico Albertazzi, Elena Fratini, Elena Sophia Consiglieri, Giulia Giannelli, Stefania Dionisio, Francesca Sartirana, Claudia Racca, Sara Camesasca, Chiara Peretto, Giovanni Daverio, Rita Esposito, Antonio De Cobelli, Francesco Silvani, Paolo Rabusin, Marco Cara, Andrea Trabattoni, Daria Dispinseri, Stefania Scarlatti, Gabriella Piemonti, Lorenzo Lampasona, Vito Cicalese, Maria Pia Aiuti, Alessandro Ferrua, Francesca Front Immunol Immunology In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype. Frontiers Media S.A. 2020-11-24 /pmc/articles/PMC7732473/ /pubmed/33329599 http://dx.doi.org/10.3389/fimmu.2020.603428 Text en Copyright © 2020 Cenciarelli, Calbi, Barzaghi, Bernardo, Oltolini, Migliavacca, Gallo, Tucci, Fraschetta, Albertazzi, Fratini, Consiglieri, Giannelli, Dionisio, Sartirana, Racca, Camesasca, Peretto, Daverio, Esposito, De Cobelli, Silvani, Rabusin, Cara, Trabattoni, Dispinseri, Scarlatti, Piemonti, Lampasona, Cicalese, Aiuti and Ferrua http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cenciarelli, Sabina
Calbi, Valeria
Barzaghi, Federica
Bernardo, Maria Ester
Oltolini, Chiara
Migliavacca, Maddalena
Gallo, Vera
Tucci, Francesca
Fraschetta, Federico
Albertazzi, Elena
Fratini, Elena Sophia
Consiglieri, Giulia
Giannelli, Stefania
Dionisio, Francesca
Sartirana, Claudia
Racca, Sara
Camesasca, Chiara
Peretto, Giovanni
Daverio, Rita
Esposito, Antonio
De Cobelli, Francesco
Silvani, Paolo
Rabusin, Marco
Cara, Andrea
Trabattoni, Daria
Dispinseri, Stefania
Scarlatti, Gabriella
Piemonti, Lorenzo
Lampasona, Vito
Cicalese, Maria Pia
Aiuti, Alessandro
Ferrua, Francesca
Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title_full Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title_fullStr Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title_full_unstemmed Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title_short Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
title_sort mild sars-cov-2 infection after gene therapy in a child with wiskott-aldrich syndrome: a case report
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732473/
https://www.ncbi.nlm.nih.gov/pubmed/33329599
http://dx.doi.org/10.3389/fimmu.2020.603428
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