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Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gen...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732473/ https://www.ncbi.nlm.nih.gov/pubmed/33329599 http://dx.doi.org/10.3389/fimmu.2020.603428 |
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author | Cenciarelli, Sabina Calbi, Valeria Barzaghi, Federica Bernardo, Maria Ester Oltolini, Chiara Migliavacca, Maddalena Gallo, Vera Tucci, Francesca Fraschetta, Federico Albertazzi, Elena Fratini, Elena Sophia Consiglieri, Giulia Giannelli, Stefania Dionisio, Francesca Sartirana, Claudia Racca, Sara Camesasca, Chiara Peretto, Giovanni Daverio, Rita Esposito, Antonio De Cobelli, Francesco Silvani, Paolo Rabusin, Marco Cara, Andrea Trabattoni, Daria Dispinseri, Stefania Scarlatti, Gabriella Piemonti, Lorenzo Lampasona, Vito Cicalese, Maria Pia Aiuti, Alessandro Ferrua, Francesca |
author_facet | Cenciarelli, Sabina Calbi, Valeria Barzaghi, Federica Bernardo, Maria Ester Oltolini, Chiara Migliavacca, Maddalena Gallo, Vera Tucci, Francesca Fraschetta, Federico Albertazzi, Elena Fratini, Elena Sophia Consiglieri, Giulia Giannelli, Stefania Dionisio, Francesca Sartirana, Claudia Racca, Sara Camesasca, Chiara Peretto, Giovanni Daverio, Rita Esposito, Antonio De Cobelli, Francesco Silvani, Paolo Rabusin, Marco Cara, Andrea Trabattoni, Daria Dispinseri, Stefania Scarlatti, Gabriella Piemonti, Lorenzo Lampasona, Vito Cicalese, Maria Pia Aiuti, Alessandro Ferrua, Francesca |
author_sort | Cenciarelli, Sabina |
collection | PubMed |
description | In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype. |
format | Online Article Text |
id | pubmed-7732473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77324732020-12-15 Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report Cenciarelli, Sabina Calbi, Valeria Barzaghi, Federica Bernardo, Maria Ester Oltolini, Chiara Migliavacca, Maddalena Gallo, Vera Tucci, Francesca Fraschetta, Federico Albertazzi, Elena Fratini, Elena Sophia Consiglieri, Giulia Giannelli, Stefania Dionisio, Francesca Sartirana, Claudia Racca, Sara Camesasca, Chiara Peretto, Giovanni Daverio, Rita Esposito, Antonio De Cobelli, Francesco Silvani, Paolo Rabusin, Marco Cara, Andrea Trabattoni, Daria Dispinseri, Stefania Scarlatti, Gabriella Piemonti, Lorenzo Lampasona, Vito Cicalese, Maria Pia Aiuti, Alessandro Ferrua, Francesca Front Immunol Immunology In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype. Frontiers Media S.A. 2020-11-24 /pmc/articles/PMC7732473/ /pubmed/33329599 http://dx.doi.org/10.3389/fimmu.2020.603428 Text en Copyright © 2020 Cenciarelli, Calbi, Barzaghi, Bernardo, Oltolini, Migliavacca, Gallo, Tucci, Fraschetta, Albertazzi, Fratini, Consiglieri, Giannelli, Dionisio, Sartirana, Racca, Camesasca, Peretto, Daverio, Esposito, De Cobelli, Silvani, Rabusin, Cara, Trabattoni, Dispinseri, Scarlatti, Piemonti, Lampasona, Cicalese, Aiuti and Ferrua http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Cenciarelli, Sabina Calbi, Valeria Barzaghi, Federica Bernardo, Maria Ester Oltolini, Chiara Migliavacca, Maddalena Gallo, Vera Tucci, Francesca Fraschetta, Federico Albertazzi, Elena Fratini, Elena Sophia Consiglieri, Giulia Giannelli, Stefania Dionisio, Francesca Sartirana, Claudia Racca, Sara Camesasca, Chiara Peretto, Giovanni Daverio, Rita Esposito, Antonio De Cobelli, Francesco Silvani, Paolo Rabusin, Marco Cara, Andrea Trabattoni, Daria Dispinseri, Stefania Scarlatti, Gabriella Piemonti, Lorenzo Lampasona, Vito Cicalese, Maria Pia Aiuti, Alessandro Ferrua, Francesca Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title | Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title_full | Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title_fullStr | Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title_full_unstemmed | Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title_short | Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report |
title_sort | mild sars-cov-2 infection after gene therapy in a child with wiskott-aldrich syndrome: a case report |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732473/ https://www.ncbi.nlm.nih.gov/pubmed/33329599 http://dx.doi.org/10.3389/fimmu.2020.603428 |
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