Comparable Intestinal and Hepatic First-Pass Effect of YL-IPA08 on the Bioavailability and Effective Brain Exposure, a Rapid Anti-PTSD and Anti-Depression Compound

YL-IPA08, exerting rapid antidepressant-like and anxiolytic-like effects on behaviors by translocator protein (TSPO) mediation, is a novel compound that has been discovered and developed at our institute. Fit-for-purpose pharmacokinetic properties is urgently needed to be discovered as early as poss...

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Detalles Bibliográficos
Autores principales: Gao, You, Yang, Chunmiao, Wang, Lingchao, Xiang, Yanan, Zhang, Wenpeng, Li, Yunfeng, Zhuang, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732531/
https://www.ncbi.nlm.nih.gov/pubmed/33328995
http://dx.doi.org/10.3389/fphar.2020.588127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732531/
https://www.ncbi.nlm.nih.gov/pubmed/33328995
http://dx.doi.org/10.3389/fphar.2020.588127

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