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Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System
Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732603/ https://www.ncbi.nlm.nih.gov/pubmed/33328896 http://dx.doi.org/10.3389/fncel.2020.600758 |
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author | Zhang, Isis Hu, Huijuan |
author_facet | Zhang, Isis Hu, Huijuan |
author_sort | Zhang, Isis |
collection | PubMed |
description | Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer’s disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies. |
format | Online Article Text |
id | pubmed-7732603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77326032020-12-15 Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System Zhang, Isis Hu, Huijuan Front Cell Neurosci Neuroscience Store-operated calcium channels (SOCs) are widely expressed in excitatory and non-excitatory cells where they mediate significant store-operated calcium entry (SOCE), an important pathway for calcium signaling throughout the body. While the activity of SOCs has been well studied in non-excitable cells, attention has turned to their role in neurons and glia in recent years. In particular, the role of SOCs in the nervous system has been extensively investigated, with links to their dysregulation found in a wide variety of neurological diseases from Alzheimer’s disease (AD) to pain. In this review, we provide an overview of their molecular components, expression, and physiological role in the nervous system and describe how the dysregulation of those roles could potentially lead to various neurological disorders. Although further studies are still needed to understand how SOCs are activated under physiological conditions and how they are linked to pathological states, growing evidence indicates that SOCs are important players in neurological disorders and could be potential new targets for therapies. While the role of SOCE in the nervous system continues to be multifaceted and controversial, the study of SOCs provides a potentially fruitful avenue into better understanding the nervous system and its pathologies. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7732603/ /pubmed/33328896 http://dx.doi.org/10.3389/fncel.2020.600758 Text en Copyright © 2020 Zhang and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhang, Isis Hu, Huijuan Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title_full | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title_fullStr | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title_full_unstemmed | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title_short | Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System |
title_sort | store-operated calcium channels in physiological and pathological states of the nervous system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732603/ https://www.ncbi.nlm.nih.gov/pubmed/33328896 http://dx.doi.org/10.3389/fncel.2020.600758 |
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