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On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model

Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by pa...

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Autores principales: Torrecillas-Martínez, Laura, Catena, Andrés, O'Valle, Francisco, Solano-Galvis, César, Padial-Molina, Miguel, Galindo-Moreno, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732636/
https://www.ncbi.nlm.nih.gov/pubmed/33328926
http://dx.doi.org/10.3389/fnhum.2020.558703
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author Torrecillas-Martínez, Laura
Catena, Andrés
O'Valle, Francisco
Solano-Galvis, César
Padial-Molina, Miguel
Galindo-Moreno, Pablo
author_facet Torrecillas-Martínez, Laura
Catena, Andrés
O'Valle, Francisco
Solano-Galvis, César
Padial-Molina, Miguel
Galindo-Moreno, Pablo
author_sort Torrecillas-Martínez, Laura
collection PubMed
description Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular impacted third molar using diffusion tensor imaging (DTI) analysis. Methods: 30 participants reported their subjective pain using a visual analog scale at three postsurgical stages: under anesthesia, in pain, and after the administration of an analgesic. The diffusion data were acquired prior to surgery. Results: DTI analysis yielded significant positive associations of fractional anisotropy in white matter areas related to pain processing (corticospinal tract, corona radiata, corpus callosum) with the differences in pain between the three postsurgery stages. Extent and location of these associations depended on the magnitude of the subjective pain differences. Tractography analysis indicated that some pain–tract associations are significant only when pain stage is involved in the contrast (posterior corona radiata), while others (middle cerebellar peduncle, pontine crossing) are only when anesthesia is involved in the contrast. Conclusions: The association of white matter fractional anisotropy and connectivity, measured before the pain stages, with subjective pain depends on the magnitude of the differences in pain scores.
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spelling pubmed-77326362020-12-15 On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model Torrecillas-Martínez, Laura Catena, Andrés O'Valle, Francisco Solano-Galvis, César Padial-Molina, Miguel Galindo-Moreno, Pablo Front Hum Neurosci Human Neuroscience Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular impacted third molar using diffusion tensor imaging (DTI) analysis. Methods: 30 participants reported their subjective pain using a visual analog scale at three postsurgical stages: under anesthesia, in pain, and after the administration of an analgesic. The diffusion data were acquired prior to surgery. Results: DTI analysis yielded significant positive associations of fractional anisotropy in white matter areas related to pain processing (corticospinal tract, corona radiata, corpus callosum) with the differences in pain between the three postsurgery stages. Extent and location of these associations depended on the magnitude of the subjective pain differences. Tractography analysis indicated that some pain–tract associations are significant only when pain stage is involved in the contrast (posterior corona radiata), while others (middle cerebellar peduncle, pontine crossing) are only when anesthesia is involved in the contrast. Conclusions: The association of white matter fractional anisotropy and connectivity, measured before the pain stages, with subjective pain depends on the magnitude of the differences in pain scores. Frontiers Media S.A. 2020-11-24 /pmc/articles/PMC7732636/ /pubmed/33328926 http://dx.doi.org/10.3389/fnhum.2020.558703 Text en Copyright © 2020 Torrecillas-Martínez, Catena, O'Valle, Solano-Galvis, Padial-Molina and Galindo-Moreno. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Torrecillas-Martínez, Laura
Catena, Andrés
O'Valle, Francisco
Solano-Galvis, César
Padial-Molina, Miguel
Galindo-Moreno, Pablo
On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title_full On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title_fullStr On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title_full_unstemmed On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title_short On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model
title_sort on the relationship between white matter structure and subjective pain. lessons from an acute surgical pain model
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732636/
https://www.ncbi.nlm.nih.gov/pubmed/33328926
http://dx.doi.org/10.3389/fnhum.2020.558703
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