Cargando…
A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease
Background: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, and its susceptibility is closely associated with genetic modifications. The association between inflammation and CAD has been investigated in detail. This meta-analysis was conducted based on the PRISMA guid...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732687/ https://www.ncbi.nlm.nih.gov/pubmed/33329013 http://dx.doi.org/10.3389/fphys.2020.539288 |
_version_ | 1783622149223743488 |
---|---|
author | Liu, Shuyan Wang, Xiju Yu, Shoujun Yan, Miao Peng, Yue Zhang, Guilong Xu, Zhaowei |
author_facet | Liu, Shuyan Wang, Xiju Yu, Shoujun Yan, Miao Peng, Yue Zhang, Guilong Xu, Zhaowei |
author_sort | Liu, Shuyan |
collection | PubMed |
description | Background: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, and its susceptibility is closely associated with genetic modifications. The association between inflammation and CAD has been investigated in detail. This meta-analysis was conducted based on the PRISMA guidelines to evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3861950 T > C and rs1234313 A > G) and the risk of CAD. Methods: The selected criteria included 11 eligible articles containing 18 studies (nine studies included 7,395 cases and 5,296 controls for rs3861950 and nine studies with 6,951 cases and 4,959 controls for rs1234313). Correlations between the two polymorphisms and CAD were estimated by pooling the odds ratios (ORs) with 95% confidence interval (95% CI) in allelic, dominant, recessive, heterozygous, and homozygous models. Results: The pooled analyses demonstrated that the rs3861950 T > C polymorphism was significantly associated with an increased risk of CAD in the Asian population in the allelic model, dominant model, and homozygous model. Furthermore, subgroup analysis based on disease type showed that TNFSF4 rs3861950 T > C had a robust correlation with increased risk of cerebral infarction (CI) in the allelic model, dominant model, heterozygous model, and homozygous model. However, the rs1234313 A > G polymorphism mostly tended to decrease the risk of CAD in the Asian and Caucasian populations in the allelic and dominant model. This single nucleotide polymorphism (SNP) had a close relation to myocardial infarction (MI) susceptibility in the allelic model, dominant model, and heterozygous model. Conclusion: This meta-analysis identified two novel SNPs in TNFSF4 significantly associated with CAD susceptibility. |
format | Online Article Text |
id | pubmed-7732687 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77326872020-12-15 A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease Liu, Shuyan Wang, Xiju Yu, Shoujun Yan, Miao Peng, Yue Zhang, Guilong Xu, Zhaowei Front Physiol Physiology Background: Coronary artery disease (CAD) remains the leading cause of mortality worldwide, and its susceptibility is closely associated with genetic modifications. The association between inflammation and CAD has been investigated in detail. This meta-analysis was conducted based on the PRISMA guidelines to evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms (rs3861950 T > C and rs1234313 A > G) and the risk of CAD. Methods: The selected criteria included 11 eligible articles containing 18 studies (nine studies included 7,395 cases and 5,296 controls for rs3861950 and nine studies with 6,951 cases and 4,959 controls for rs1234313). Correlations between the two polymorphisms and CAD were estimated by pooling the odds ratios (ORs) with 95% confidence interval (95% CI) in allelic, dominant, recessive, heterozygous, and homozygous models. Results: The pooled analyses demonstrated that the rs3861950 T > C polymorphism was significantly associated with an increased risk of CAD in the Asian population in the allelic model, dominant model, and homozygous model. Furthermore, subgroup analysis based on disease type showed that TNFSF4 rs3861950 T > C had a robust correlation with increased risk of cerebral infarction (CI) in the allelic model, dominant model, heterozygous model, and homozygous model. However, the rs1234313 A > G polymorphism mostly tended to decrease the risk of CAD in the Asian and Caucasian populations in the allelic and dominant model. This single nucleotide polymorphism (SNP) had a close relation to myocardial infarction (MI) susceptibility in the allelic model, dominant model, and heterozygous model. Conclusion: This meta-analysis identified two novel SNPs in TNFSF4 significantly associated with CAD susceptibility. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7732687/ /pubmed/33329013 http://dx.doi.org/10.3389/fphys.2020.539288 Text en Copyright © 2020 Liu, Wang, Yu, Yan, Peng, Zhang and Xu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Liu, Shuyan Wang, Xiju Yu, Shoujun Yan, Miao Peng, Yue Zhang, Guilong Xu, Zhaowei A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title | A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title_full | A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title_fullStr | A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title_full_unstemmed | A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title_short | A Meta-Analysis on the Association Between TNFSF4 Polymorphisms (rs3861950 T > C and rs1234313 A > G) and Susceptibility to Coronary Artery Disease |
title_sort | meta-analysis on the association between tnfsf4 polymorphisms (rs3861950 t > c and rs1234313 a > g) and susceptibility to coronary artery disease |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732687/ https://www.ncbi.nlm.nih.gov/pubmed/33329013 http://dx.doi.org/10.3389/fphys.2020.539288 |
work_keys_str_mv | AT liushuyan ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT wangxiju ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT yushoujun ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT yanmiao ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT pengyue ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT zhangguilong ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT xuzhaowei ametaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT liushuyan metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT wangxiju metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT yushoujun metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT yanmiao metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT pengyue metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT zhangguilong metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease AT xuzhaowei metaanalysisontheassociationbetweentnfsf4polymorphismsrs3861950tcandrs1234313agandsusceptibilitytocoronaryarterydisease |