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Gray matter declines with age and hearing loss, but is partially maintained in tinnitus
The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732822/ https://www.ncbi.nlm.nih.gov/pubmed/33311548 http://dx.doi.org/10.1038/s41598-020-78571-0 |
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author | Koops, Elouise A. de Kleine, Emile van Dijk, Pim |
author_facet | Koops, Elouise A. de Kleine, Emile van Dijk, Pim |
author_sort | Koops, Elouise A. |
collection | PubMed |
description | The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline. |
format | Online Article Text |
id | pubmed-7732822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77328222020-12-14 Gray matter declines with age and hearing loss, but is partially maintained in tinnitus Koops, Elouise A. de Kleine, Emile van Dijk, Pim Sci Rep Article The impact of age-related hearing loss extends beyond the auditory pathway and impacts brain areas related to cognitive impairment and even dementia. The presence of tinnitus, a sensation of sound that frequently co-occurs with hearing loss, is additionally linked to cognitive decline. Interestingly, structural neuroimaging studies have reported that hearing loss may precede or modulate the onset of cognitive impairment. In this study, we aimed to disentangle the effects of age, hearing loss, and tinnitus on gray matter structure. In total, 39 participants with hearing loss and tinnitus, 21 with hearing loss but without tinnitus, and 39 controls were included in this voxel- and surface-based morphometry MRI study. Whole brain volume and surface thickness measures were compared between the groups. Age-related gray matter volume decline was observed in all groups. Several brain areas showed smaller gray matter volume and cortical surface thickness in hearing loss without tinnitus, relative to controls. This reduction was observed both within and outside of the auditory pathway. Interestingly, these reductions were not observed in participants with tinnitus, who had similar hearing loss and were of similar age. Since we have tools to improve hearing loss, hearing screening may aid in the battle against cognitive decline. Nature Publishing Group UK 2020-12-11 /pmc/articles/PMC7732822/ /pubmed/33311548 http://dx.doi.org/10.1038/s41598-020-78571-0 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Koops, Elouise A. de Kleine, Emile van Dijk, Pim Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title | Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title_full | Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title_fullStr | Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title_full_unstemmed | Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title_short | Gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
title_sort | gray matter declines with age and hearing loss, but is partially maintained in tinnitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732822/ https://www.ncbi.nlm.nih.gov/pubmed/33311548 http://dx.doi.org/10.1038/s41598-020-78571-0 |
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