Cargando…
Altered diversity and composition of gut microbiota in Wilson's disease
Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732847/ https://www.ncbi.nlm.nih.gov/pubmed/33311635 http://dx.doi.org/10.1038/s41598-020-78988-7 |
_version_ | 1783622177176682496 |
---|---|
author | Cai, Xiangsheng Deng, Lin Ma, Xiaogui Guo, Yusheng Feng, Zhiting Liu, Minqi Guan, Yubin Huang, Yanting Deng, Jianxin Li, Hongwei Sang, Hong Liu, Fang Yang, Xiaorong |
author_facet | Cai, Xiangsheng Deng, Lin Ma, Xiaogui Guo, Yusheng Feng, Zhiting Liu, Minqi Guan, Yubin Huang, Yanting Deng, Jianxin Li, Hongwei Sang, Hong Liu, Fang Yang, Xiaorong |
author_sort | Cai, Xiangsheng |
collection | PubMed |
description | Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal microbiota polymorphism in WD have not been fully elaborated and need to be explore for seeking some microbiota benefit for WD patients. In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and was compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. The WD group presented unique richness of Gemellaceae, Pseudomonadaceae and Spirochaetaceae at family level, which were hardly detected in healthy controls. The WD group had a markedly lower abundance of Actinobacteria, Firmicutes and Verrucomicrobia, and a higher abundance of Bacteroidetes, Proteobacteria, Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. In addition, the functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the host immune and metabolism associated systems pathways such as transcription factors and ABC-type transporters, compared to healthy individuals. These results implied dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD, which may provide a new understanding of the pathogenesis and new possible therapeutic targets for WD. |
format | Online Article Text |
id | pubmed-7732847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77328472020-12-14 Altered diversity and composition of gut microbiota in Wilson's disease Cai, Xiangsheng Deng, Lin Ma, Xiaogui Guo, Yusheng Feng, Zhiting Liu, Minqi Guan, Yubin Huang, Yanting Deng, Jianxin Li, Hongwei Sang, Hong Liu, Fang Yang, Xiaorong Sci Rep Article Wilson’s disease (WD) is an autosomal recessive inherited disorder of chronic copper toxicosis with high mortality and disability. Recent evidence suggests a correlation between dysbiosis in gut microbiome and multiple diseases such as genetic and metabolic disease. However, the impact of intestinal microbiota polymorphism in WD have not been fully elaborated and need to be explore for seeking some microbiota benefit for WD patients. In this study, the 16S rRNA sequencing was performed on fecal samples from 14 patients with WD and was compared to the results from 16 healthy individuals. The diversity and composition of the gut microbiome in the WD group were significantly lower than those in healthy individuals. The WD group presented unique richness of Gemellaceae, Pseudomonadaceae and Spirochaetaceae at family level, which were hardly detected in healthy controls. The WD group had a markedly lower abundance of Actinobacteria, Firmicutes and Verrucomicrobia, and a higher abundance of Bacteroidetes, Proteobacteria, Cyanobacteria and Fusobacteria than that in healthy individuals. The Firmicutes to Bacteroidetes ratio in the WD group was significantly lower than that of healthy control. In addition, the functional profile of the gut microbiome from WD patients showed a lower abundance of bacterial groups involved in the host immune and metabolism associated systems pathways such as transcription factors and ABC-type transporters, compared to healthy individuals. These results implied dysbiosis of gut microbiota may be influenced by the host metabolic disorders of WD, which may provide a new understanding of the pathogenesis and new possible therapeutic targets for WD. Nature Publishing Group UK 2020-12-11 /pmc/articles/PMC7732847/ /pubmed/33311635 http://dx.doi.org/10.1038/s41598-020-78988-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cai, Xiangsheng Deng, Lin Ma, Xiaogui Guo, Yusheng Feng, Zhiting Liu, Minqi Guan, Yubin Huang, Yanting Deng, Jianxin Li, Hongwei Sang, Hong Liu, Fang Yang, Xiaorong Altered diversity and composition of gut microbiota in Wilson's disease |
title | Altered diversity and composition of gut microbiota in Wilson's disease |
title_full | Altered diversity and composition of gut microbiota in Wilson's disease |
title_fullStr | Altered diversity and composition of gut microbiota in Wilson's disease |
title_full_unstemmed | Altered diversity and composition of gut microbiota in Wilson's disease |
title_short | Altered diversity and composition of gut microbiota in Wilson's disease |
title_sort | altered diversity and composition of gut microbiota in wilson's disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732847/ https://www.ncbi.nlm.nih.gov/pubmed/33311635 http://dx.doi.org/10.1038/s41598-020-78988-7 |
work_keys_str_mv | AT caixiangsheng altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT denglin altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT maxiaogui altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT guoyusheng altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT fengzhiting altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT liuminqi altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT guanyubin altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT huangyanting altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT dengjianxin altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT lihongwei altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT sanghong altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT liufang altereddiversityandcompositionofgutmicrobiotainwilsonsdisease AT yangxiaorong altereddiversityandcompositionofgutmicrobiotainwilsonsdisease |