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Imaging the role of blood–brain barrier disruption in normal cognitive ageing

To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample...

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Autores principales: Verheggen, Inge C. M., de Jong, Joost J. A., van Boxtel, Martin P. J., Postma, Alida A., Jansen, Jacobus F. A., Verhey, Frans R. J., Backes, Walter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732959/
https://www.ncbi.nlm.nih.gov/pubmed/33025410
http://dx.doi.org/10.1007/s11357-020-00282-1
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author Verheggen, Inge C. M.
de Jong, Joost J. A.
van Boxtel, Martin P. J.
Postma, Alida A.
Jansen, Jacobus F. A.
Verhey, Frans R. J.
Backes, Walter H.
author_facet Verheggen, Inge C. M.
de Jong, Joost J. A.
van Boxtel, Martin P. J.
Postma, Alida A.
Jansen, Jacobus F. A.
Verhey, Frans R. J.
Backes, Walter H.
author_sort Verheggen, Inge C. M.
collection PubMed
description To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was measured using DCE MRI with pharmacokinetic modelling. Regression analysis was performed to investigate whether the leakage rate was associated with decline in cognitive performance (memory encoding, memory retrieval, executive functioning and processing speed) over 12 years. White and grey matter BBB leakages were significantly associated with decline in memory retrieval. No significant relations were found between hippocampal BBB leakage and cognitive performance. BBB disruption already being associated with usual cognitive ageing, supports that this neurovascular alteration is a possible explanation for the cognitive decline inherent to the ageing process. More insight into BBB leakage during the normal ageing process could improve estimation and interpretation of leakage rate in pathological conditions. The current results might also stimulate the search for strategies to maintain BBB integrity and help increase the proportion people experiencing successful ageing. Netherlands Trial Register number: NL6358, date of registration: 2017-03-24.
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spelling pubmed-77329592020-12-21 Imaging the role of blood–brain barrier disruption in normal cognitive ageing Verheggen, Inge C. M. de Jong, Joost J. A. van Boxtel, Martin P. J. Postma, Alida A. Jansen, Jacobus F. A. Verhey, Frans R. J. Backes, Walter H. GeroScience Original Article To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI to measure BBB leakage in a healthy sample, and investigated the association with longitudinal cognitive decline. In a sample of neurologically and cognitively healthy, older individuals, BBB leakage rate in the white and grey matter and hippocampus was measured using DCE MRI with pharmacokinetic modelling. Regression analysis was performed to investigate whether the leakage rate was associated with decline in cognitive performance (memory encoding, memory retrieval, executive functioning and processing speed) over 12 years. White and grey matter BBB leakages were significantly associated with decline in memory retrieval. No significant relations were found between hippocampal BBB leakage and cognitive performance. BBB disruption already being associated with usual cognitive ageing, supports that this neurovascular alteration is a possible explanation for the cognitive decline inherent to the ageing process. More insight into BBB leakage during the normal ageing process could improve estimation and interpretation of leakage rate in pathological conditions. The current results might also stimulate the search for strategies to maintain BBB integrity and help increase the proportion people experiencing successful ageing. Netherlands Trial Register number: NL6358, date of registration: 2017-03-24. Springer International Publishing 2020-10-06 /pmc/articles/PMC7732959/ /pubmed/33025410 http://dx.doi.org/10.1007/s11357-020-00282-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Verheggen, Inge C. M.
de Jong, Joost J. A.
van Boxtel, Martin P. J.
Postma, Alida A.
Jansen, Jacobus F. A.
Verhey, Frans R. J.
Backes, Walter H.
Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title_full Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title_fullStr Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title_full_unstemmed Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title_short Imaging the role of blood–brain barrier disruption in normal cognitive ageing
title_sort imaging the role of blood–brain barrier disruption in normal cognitive ageing
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732959/
https://www.ncbi.nlm.nih.gov/pubmed/33025410
http://dx.doi.org/10.1007/s11357-020-00282-1
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