Cargando…

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion

Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling is associated with gut homeostasis and barrier integrity. However, the biological function and regulation of STING signaling in intestinal I/R injury are not yet fu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xufei, Wu, Jie, Liu, Qinjie, Li, Xuanheng, Li, Sicheng, Chen, Jun, Hong, Zhiwu, Wu, Xiuwen, Zhao, Yun, Ren, Jianan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732985/ https://www.ncbi.nlm.nih.gov/pubmed/33311495 http://dx.doi.org/10.1038/s41419-020-03239-6

Ejemplares similares

Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury
por: Liu, Qinjie, et al.
Publicado: (2021)

RIPK3–MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis
por: Zhang, Xufei, et al.
Publicado: (2023)

The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages
por: Wu, Jie, et al.
Publicado: (2022)

Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury
por: Wen, Shihong, et al.
Publicado: (2016)

Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction
por: Hu, Qiongyuan, et al.
Publicado: (2018)

GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
por: Zhao, Chen, et al.
Publicado: (2023)

Author Correction: Released mitochondrial DNA following intestinal ischemia reperfusion induces the inflammatory response and gut barrier dysfunction
por: Hu, Qiongyuan, et al.
Publicado: (2022)

Post-Translational Modifications of STING: A Potential Therapeutic Target
por: Kang, Jiaqi, et al.
Publicado: (2022)

Pharmaceutical Therapies for Necroptosis in Myocardial Ischemia–Reperfusion Injury
por: Zhang, Yinchang, et al.
Publicado: (2023)

Rapid Reversal of Human Intestinal Ischemia-Reperfusion Induced Damage by Shedding of Injured Enterocytes and Reepithelialisation
por: Derikx, Joep P. M., et al.
Publicado: (2008)

Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
por: Suissa, Sarit, et al.
Publicado: (2009)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway
por: Li, Yujia, et al.
Publicado: (2022)

Dynamics of necroptosis in kidney ischemia-reperfusion injury
por: Pefanis, Aspasia, et al.
Publicado: (2023)

STING-mediated intestinal barrier dysfunction contributes to lethal sepsis
por: Hu, Qiongyuan, et al.
Publicado: (2019)

IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING
por: Zeng, Xue, et al.
Publicado: (2022)

Where mtDNA is made
por: LeBrasseur, Nicole
Publicado: (2003)

Melanesian mtDNA Complexity
por: Friedlaender, Jonathan S., et al.
Publicado: (2007)

Lactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome
por: Xu, Jiabao, et al.
Publicado: (2023)

Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release
por: Xu, Lei, et al.
Publicado: (2022)

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy
por: van Tienen, Florence, et al.
Publicado: (2019)

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation
por: Fan, Zhen, et al.
Publicado: (2023)

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes
por: Ma, Xiu Mei, et al.
Publicado: (2022)

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion
por: Gkirtzimanaki, Katerina, et al.
Publicado: (2018)

The STING pathway does not contribute to behavioural or mitochondrial phenotypes in Drosophila Pink1/parkin or mtDNA mutator models
por: Lee, Juliette J., et al.
Publicado: (2020)

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
por: Hancock-Cerutti, William, et al.
Publicado: (2022)

STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice
por: Zhang, Qin, et al.
Publicado: (2022)

Comprehensive analysis of necroptosis-related genes in renal ischemia-reperfusion injury
por: Li, Shuai, et al.
Publicado: (2023)

GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes
por: Wang, Haisong, et al.
Publicado: (2020)

Origins and Evolution of the Etruscans’ mtDNA
por: Ghirotto, Silvia, et al.
Publicado: (2013)

mtDNA in the Pathogenesis of Cardiovascular Diseases
por: Wang, Lili, et al.
Publicado: (2021)

CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation
por: Yao, Dabao, et al.
Publicado: (2021)

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease
por: Nicholls, Thomas J., et al.
Publicado: (2014)

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats
por: Chimienti, Guglielmina, et al.
Publicado: (2019)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

mtDNA Maintenance and Alterations in the Pathogenesis of Neurodegenerative Diseases
por: Shang, Dehao, et al.
Publicado: (2023)

mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke
por: Kong, Lingqi, et al.
Publicado: (2022)

Evidence for a Fourteenth mtDNA-Encoded Protein in the Female-Transmitted mtDNA of Marine Mussels (Bivalvia: Mytilidae)
por: Breton, Sophie, et al.
Publicado: (2011)

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart
por: Chimienti, Guglielmina, et al.
Publicado: (2018)

Hypervariable Region Polymorphism of mtDNA of Recurrent Oral Ulceration in Chinese
por: Sun, Mao, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_1li66ejfmulpeb5sej9d49rg48