Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

Boron-containing compounds represent a promising class of molecules with proven efficacy against a wide range of pathogens, including apicomplexan parasites. Following lead optimization, the benzoxaborole AN13762 was identified as a preclinical candidate against the human malaria parasite, yet the m...

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Detalles Bibliográficos
Autores principales: Bellini, Valeria, Swale, Christopher, Brenier-Pinchart, Marie-Pierre, Pezier, Tiffany, Georgeault, Sonia, Laurent, Fabrice, Hakimi, Mohamed-Ali, Bougdour, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733022/
https://www.ncbi.nlm.nih.gov/pubmed/33336164
http://dx.doi.org/10.1016/j.isci.2020.101871

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