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Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis
OBJECTIVE: To assess incidence and changes in tinnitus and bothersome tinnitus as well as associated risk factors in a large sample of UK adults. DESIGN: Prospective cohort study. SETTING: UK. PARTICIPANTS: For cross-sectional analysis, a group of 168 348 participants aged between 40 and 69 years wi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733183/ https://www.ncbi.nlm.nih.gov/pubmed/33303456 http://dx.doi.org/10.1136/bmjopen-2020-041290 |
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author | Dawes, Piers Newall, John Stockdale, David Baguley, David M |
author_facet | Dawes, Piers Newall, John Stockdale, David Baguley, David M |
author_sort | Dawes, Piers |
collection | PubMed |
description | OBJECTIVE: To assess incidence and changes in tinnitus and bothersome tinnitus as well as associated risk factors in a large sample of UK adults. DESIGN: Prospective cohort study. SETTING: UK. PARTICIPANTS: For cross-sectional analysis, a group of 168 348 participants aged between 40 and 69 years with hearing and tinnitus data from the UK Biobank resource. Longitudinal analysis included a subset of 4746 people who attended a 4-year retest assessment. MAIN OUTCOME MEASURES: Presence and bothersomeness of tinnitus. RESULTS: 17.7% and 5.8% of participants reported tinnitus or bothersome tinnitus, respectively. The 4-year incidence of tinnitus was 8.7%. Multivariate logistic regression models suggested that age, hearing difficulties, work noise exposure, ototoxic medication and neuroticism were all positively associated with both tinnitus and bothersome tinnitus. Reduced odds of tinnitus, but not bothersome tinnitus, was seen in alcohol drinkers versus non-drinkers. Male gender was associated with increased odds of tinnitus, while female gender was associated with increased odds of bothersome tinnitus. At follow-up, of those originally reporting tinnitus, 18.3% reported no tinnitus. Of those still reporting tinnitus, 9% reported improvement and 9% reported tinnitus becoming more bothersome, with the rest unchanged. Male gender and alcohol consumption were associated with tinnitus being reported less bothersome, and hearing difficulties were associated with the odds of tinnitus being reported as more bothersome. CONCLUSIONS: This study is one of the few to provide data on the natural history of tinnitus in a non-clinical population, suggesting that resolution is relatively uncommon, with improvement and worsening of symptoms equally likely. There was limited evidence for any modifiable lifestyle factors being associated with changes in tinnitus symptoms. In view of the largely persistent nature of tinnitus, public health strategies should focus on: (1) primary prevention and (2) managing symptoms in people that have tinnitus and monitoring changes in bothersomeness. |
format | Online Article Text |
id | pubmed-7733183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-77331832020-12-21 Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis Dawes, Piers Newall, John Stockdale, David Baguley, David M BMJ Open Epidemiology OBJECTIVE: To assess incidence and changes in tinnitus and bothersome tinnitus as well as associated risk factors in a large sample of UK adults. DESIGN: Prospective cohort study. SETTING: UK. PARTICIPANTS: For cross-sectional analysis, a group of 168 348 participants aged between 40 and 69 years with hearing and tinnitus data from the UK Biobank resource. Longitudinal analysis included a subset of 4746 people who attended a 4-year retest assessment. MAIN OUTCOME MEASURES: Presence and bothersomeness of tinnitus. RESULTS: 17.7% and 5.8% of participants reported tinnitus or bothersome tinnitus, respectively. The 4-year incidence of tinnitus was 8.7%. Multivariate logistic regression models suggested that age, hearing difficulties, work noise exposure, ototoxic medication and neuroticism were all positively associated with both tinnitus and bothersome tinnitus. Reduced odds of tinnitus, but not bothersome tinnitus, was seen in alcohol drinkers versus non-drinkers. Male gender was associated with increased odds of tinnitus, while female gender was associated with increased odds of bothersome tinnitus. At follow-up, of those originally reporting tinnitus, 18.3% reported no tinnitus. Of those still reporting tinnitus, 9% reported improvement and 9% reported tinnitus becoming more bothersome, with the rest unchanged. Male gender and alcohol consumption were associated with tinnitus being reported less bothersome, and hearing difficulties were associated with the odds of tinnitus being reported as more bothersome. CONCLUSIONS: This study is one of the few to provide data on the natural history of tinnitus in a non-clinical population, suggesting that resolution is relatively uncommon, with improvement and worsening of symptoms equally likely. There was limited evidence for any modifiable lifestyle factors being associated with changes in tinnitus symptoms. In view of the largely persistent nature of tinnitus, public health strategies should focus on: (1) primary prevention and (2) managing symptoms in people that have tinnitus and monitoring changes in bothersomeness. BMJ Publishing Group 2020-12-10 /pmc/articles/PMC7733183/ /pubmed/33303456 http://dx.doi.org/10.1136/bmjopen-2020-041290 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Epidemiology Dawes, Piers Newall, John Stockdale, David Baguley, David M Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title | Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title_full | Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title_fullStr | Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title_full_unstemmed | Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title_short | Natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
title_sort | natural history of tinnitus in adults: a cross-sectional and longitudinal analysis |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733183/ https://www.ncbi.nlm.nih.gov/pubmed/33303456 http://dx.doi.org/10.1136/bmjopen-2020-041290 |
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