Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV–bacterial coinfection. Overall, 12( )144 hospitalized patients with AR...

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Autores principales: Godefroy, Raphael, Giraud-gatineau, Audrey, Jimeno, Marie-Thérèse, Edouard, Sophie, Meddeb, Line, Zandotti, Christine, Chaudet, Hervé, Colson, Philippe, Raoult, Didier, Cassir, Nadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733236/
https://www.ncbi.nlm.nih.gov/pubmed/33335940
http://dx.doi.org/10.1093/ofid/ofaa546
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author Godefroy, Raphael
Giraud-gatineau, Audrey
Jimeno, Marie-Thérèse
Edouard, Sophie
Meddeb, Line
Zandotti, Christine
Chaudet, Hervé
Colson, Philippe
Raoult, Didier
Cassir, Nadim
author_facet Godefroy, Raphael
Giraud-gatineau, Audrey
Jimeno, Marie-Thérèse
Edouard, Sophie
Meddeb, Line
Zandotti, Christine
Chaudet, Hervé
Colson, Philippe
Raoult, Didier
Cassir, Nadim
author_sort Godefroy, Raphael
collection PubMed
description Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV–bacterial coinfection. Overall, 12( )144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV–bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30–6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.
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spelling pubmed-77332362020-12-16 Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults Godefroy, Raphael Giraud-gatineau, Audrey Jimeno, Marie-Thérèse Edouard, Sophie Meddeb, Line Zandotti, Christine Chaudet, Hervé Colson, Philippe Raoult, Didier Cassir, Nadim Open Forum Infect Dis Brief Reports Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV–bacterial coinfection. Overall, 12( )144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV–bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30–6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed. Oxford University Press 2020-11-12 /pmc/articles/PMC7733236/ /pubmed/33335940 http://dx.doi.org/10.1093/ofid/ofaa546 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Godefroy, Raphael
Giraud-gatineau, Audrey
Jimeno, Marie-Thérèse
Edouard, Sophie
Meddeb, Line
Zandotti, Christine
Chaudet, Hervé
Colson, Philippe
Raoult, Didier
Cassir, Nadim
Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title_full Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title_fullStr Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title_full_unstemmed Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title_short Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults
title_sort respiratory syncytial virus infection: its propensity for bacterial coinfection and related mortality in elderly adults
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733236/
https://www.ncbi.nlm.nih.gov/pubmed/33335940
http://dx.doi.org/10.1093/ofid/ofaa546
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