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Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma
BACKGROUND: The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma. METHODS: We retrospectively anal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733294/ https://www.ncbi.nlm.nih.gov/pubmed/33308323 http://dx.doi.org/10.1186/s40644-020-00363-6 |
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author | Sun, Fenghao Huang, Yiwei Yang, Xiaodong Zhan, Cheng Xi, Junjie Lin, Zongwu Shi, Yu Jiang, Wei Wang, Qun |
author_facet | Sun, Fenghao Huang, Yiwei Yang, Xiaodong Zhan, Cheng Xi, Junjie Lin, Zongwu Shi, Yu Jiang, Wei Wang, Qun |
author_sort | Sun, Fenghao |
collection | PubMed |
description | BACKGROUND: The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma. METHODS: We retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS). RESULTS: Four hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections. CONCLUSION: A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-020-00363-6. |
format | Online Article Text |
id | pubmed-7733294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77332942020-12-14 Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma Sun, Fenghao Huang, Yiwei Yang, Xiaodong Zhan, Cheng Xi, Junjie Lin, Zongwu Shi, Yu Jiang, Wei Wang, Qun Cancer Imaging Research Article BACKGROUND: The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma. METHODS: We retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS). RESULTS: Four hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections. CONCLUSION: A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40644-020-00363-6. BioMed Central 2020-12-12 /pmc/articles/PMC7733294/ /pubmed/33308323 http://dx.doi.org/10.1186/s40644-020-00363-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Sun, Fenghao Huang, Yiwei Yang, Xiaodong Zhan, Cheng Xi, Junjie Lin, Zongwu Shi, Yu Jiang, Wei Wang, Qun Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title | Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title_full | Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title_fullStr | Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title_full_unstemmed | Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title_short | Solid component ratio influences prognosis of GGO-featured IA stage invasive lung adenocarcinoma |
title_sort | solid component ratio influences prognosis of ggo-featured ia stage invasive lung adenocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733294/ https://www.ncbi.nlm.nih.gov/pubmed/33308323 http://dx.doi.org/10.1186/s40644-020-00363-6 |
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