Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

Stimulator of interferon genes (STING) is a key regulator of type I interferon and pro-inflammatory responses during infection, cellular stress, and cancer. Here, we reveal a mechanism for how STING balances activation of IRF3- and NF-κB-dependent transcription and discover that acquisition of discr...

Descripción completa

Detalles Bibliográficos
Autores principales: de Oliveira Mann, Carina C., Orzalli, Megan H., King, David S., Kagan, Jonathan C., Lee, Amy S.Y., Kranzusch, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733315/
https://www.ncbi.nlm.nih.gov/pubmed/31018131
http://dx.doi.org/10.1016/j.celrep.2019.03.098

Ejemplares similares

Ejemplares similares