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Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark
BACKGROUND: Some neurogenerative diseases have been linked to a reduced risk of cancer, but the association between motor neuron disease and cancer risk is not well understood. We hypothesized that cancer risk would be lower among those with motor neuron disease and its most common subtype, amyotrop...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733394/ https://www.ncbi.nlm.nih.gov/pubmed/33324108 http://dx.doi.org/10.2147/CLEP.S271543 |
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author | Sørensen, Trine Toft Farkas, Dóra Körmendiné Riahi, Emil Zâl Bjerregaard Ehrenstein, Vera Henderson, Victor W |
author_facet | Sørensen, Trine Toft Farkas, Dóra Körmendiné Riahi, Emil Zâl Bjerregaard Ehrenstein, Vera Henderson, Victor W |
author_sort | Sørensen, Trine Toft |
collection | PubMed |
description | BACKGROUND: Some neurogenerative diseases have been linked to a reduced risk of cancer, but the association between motor neuron disease and cancer risk is not well understood. We hypothesized that cancer risk would be lower among those with motor neuron disease and its most common subtype, amyotrophic lateral sclerosis. METHODS: We conducted a population-based cohort study of motor neuron disease and cancer risk using routinely collected data from population-based registries in Denmark. We examined cancer incidence among patients diagnosed with motor neuron disease between January 1980 and December 2013 followed through 2013. Using Danish national cancer rates for the study period, we computed standardized incidence ratios as a measure of relative risks. RESULTS: In the cohort of 5053 patients with a motor neuron disease, the overall standardized incidence ratio of any cancer was 1.17 (95% confidence interval [CI], 1.03–1.31); the corresponding standardized incidence ratio for amyotrophic lateral sclerosis was 1.24 (95% CI, 0.96–1.57). The standardized incidence ratios of any cancer in the cohort with motor neuron disease was 1.52 (95% CI, 1.22–1.87) for <1 year of follow-up; 0.87 (95% CI, 0.68–1.09) for years 1–5 of follow-up; and 1.22 (95% CI, 1.01–1.46) for >5 years of follow-up. Beyond one year of follow-up, patients in the motor neuron disease had elevated standardized incidence ratios for lymphoid leukemia, non-Hodgkin lymphoma, and basal cell skin cancer. CONCLUSION: Findings fail to support the hypothesis that motor neuron disease or amyotrophic lateral sclerosis is associated with reduced cancer incidence. An elevated risk of cancer during the first year of follow-up may be attributable to heightened surveillance. |
format | Online Article Text |
id | pubmed-7733394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-77333942020-12-14 Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark Sørensen, Trine Toft Farkas, Dóra Körmendiné Riahi, Emil Zâl Bjerregaard Ehrenstein, Vera Henderson, Victor W Clin Epidemiol Original Research BACKGROUND: Some neurogenerative diseases have been linked to a reduced risk of cancer, but the association between motor neuron disease and cancer risk is not well understood. We hypothesized that cancer risk would be lower among those with motor neuron disease and its most common subtype, amyotrophic lateral sclerosis. METHODS: We conducted a population-based cohort study of motor neuron disease and cancer risk using routinely collected data from population-based registries in Denmark. We examined cancer incidence among patients diagnosed with motor neuron disease between January 1980 and December 2013 followed through 2013. Using Danish national cancer rates for the study period, we computed standardized incidence ratios as a measure of relative risks. RESULTS: In the cohort of 5053 patients with a motor neuron disease, the overall standardized incidence ratio of any cancer was 1.17 (95% confidence interval [CI], 1.03–1.31); the corresponding standardized incidence ratio for amyotrophic lateral sclerosis was 1.24 (95% CI, 0.96–1.57). The standardized incidence ratios of any cancer in the cohort with motor neuron disease was 1.52 (95% CI, 1.22–1.87) for <1 year of follow-up; 0.87 (95% CI, 0.68–1.09) for years 1–5 of follow-up; and 1.22 (95% CI, 1.01–1.46) for >5 years of follow-up. Beyond one year of follow-up, patients in the motor neuron disease had elevated standardized incidence ratios for lymphoid leukemia, non-Hodgkin lymphoma, and basal cell skin cancer. CONCLUSION: Findings fail to support the hypothesis that motor neuron disease or amyotrophic lateral sclerosis is associated with reduced cancer incidence. An elevated risk of cancer during the first year of follow-up may be attributable to heightened surveillance. Dove 2020-12-08 /pmc/articles/PMC7733394/ /pubmed/33324108 http://dx.doi.org/10.2147/CLEP.S271543 Text en © 2020 Sørensen et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Sørensen, Trine Toft Farkas, Dóra Körmendiné Riahi, Emil Zâl Bjerregaard Ehrenstein, Vera Henderson, Victor W Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title | Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title_full | Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title_fullStr | Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title_full_unstemmed | Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title_short | Motor Neuron Disease and Risk of Cancer: A Population-Based Cohort Study in Denmark |
title_sort | motor neuron disease and risk of cancer: a population-based cohort study in denmark |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733394/ https://www.ncbi.nlm.nih.gov/pubmed/33324108 http://dx.doi.org/10.2147/CLEP.S271543 |
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