Dynamics of Big Bubble Formation During Deep Anterior Lamellar Keratoplasty in Eyes with Advanced Keratoconus

PURPOSE: To study the dynamics of big bubble (BB) formation in eyes with advanced keratoconus (KC) during deep anterior lamellar keratoplasty (DALK). METHODS: A retrospective review of medical records and videos of DALK surgeries performed during the period from January 2013 to December 2019 on keratoconic eyes. Eyes with formed BB, in the presence of a relatively clear stroma, were included. We studied the following parameters the location of BB commencement, duration from the start of the bubble until complete formation, and the pattern of air passage during the formation process. RESULTS: A total of 37 eyes met the inclusion criteria. Type 1 BB was formed in 22 eyes with a mean formation time of 1.9 ± 1.1 seconds and a mean bubble diameter of 7.6 ± 1.1 mm. Type 1 BB started in the center as a small dome expanding centrifugally with preceding localized stromal whitening in 19 eyes and without whitening in three eyes. Type 2 BB was formed in 14 eyes with a mean formation time of 0.3 ± 0.12 seconds and a mean bubble diameter of 7.4 ± 1.8 mm. Type 2 BB started in the center in 13 eyes and the mid periphery in one eye, through either direct access to the plane between Descemet’s membrane and the pre-Descemet’s layer in six eyes, or preceded by a small intrastromal bubble in eight eyes. Mixed bubble was observed in one eye, which started as a small central Type 1 BB followed by the rapid formation of a Type 2 BB. CONCLUSION: Eyes with KC are associated with central commencements of both Type 1 and Type 2 BB during DALK. Duration of BB formation was significantly faster in Type 2 BB, with most starting as a small intrastromal bubble before air gain access to the plane between DM and stroma.