Cargando…

Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice

PURPOSE: Diallyl sulfide (DAS), one of the organo-sulfur secondary metabolites in garlic, has been shown to inhibit the proliferation of cancer cells. The present study aimed to evaluate the mechanism of DAS in the prevention of benzo[a]pyrene (BaP)-induced lung cancer in a murine model. MATERIALS A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Arif, Alhumaydhi, Fahad A, Alwashmi, Ameen S S, Allemailem, Khaled S, Alsahli, Mohammed A, Alrumaihi, Faris A, Almatroudi, Ahmad, Mobark, Mugahid A, Mousa, Ayman, Khan, Masood A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733419/ https://www.ncbi.nlm.nih.gov/pubmed/33324084 http://dx.doi.org/10.2147/JIR.S284279

Ejemplares similares

Safety, Stability, and Therapeutic Efficacy of Long-Circulating TQ-Incorporated Liposomes: Implication in the Treatment of Lung Cancer
por: Khan, Arif, et al.
Publicado: (2022)

Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice
por: Khan, Arif, et al.
Publicado: (2022)

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats
por: Almatroodi, Saleh A., et al.
Publicado: (2020)

The Effect of Liposomal Diallyl Disulfide and Oxaliplatin on Proliferation of Colorectal Cancer Cells: In Vitro and In Silico Analysis
por: Alrumaihi, Faris, et al.
Publicado: (2022)

Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
por: Alrumaihi, Faris A, et al.
Publicado: (2021)

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis
por: Khan, Arif, et al.
Publicado: (2021)

Potential of Methylglyoxal-Conjugated Chitosan Nanoparticles in Treatment of Fluconazole-Resistant Candida albicans Infection in a Murine Model
por: Khan, Shaheer Hasan, et al.
Publicado: (2020)

Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis
por: Alrumaihi, Faris, et al.
Publicado: (2022)

Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects
por: Mousa, Ayman M, et al.
Publicado: (2021)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management
por: Allemailem, Khaled S., et al.
Publicado: (2022)

Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab’-Immunoliposomes for Gene Silencing in Breast Cancer Cells
por: Khan, Arif, et al.
Publicado: (2020)

Therapeutic Effect of Bilsaan, Sambucus nigra Stem Exudate, on the OVA-Induced Allergic Asthma in Mice
por: Alrumaihi, Faris, et al.
Publicado: (2020)

To BaP or not to BaP? That is the question.
por: Goldstein, L S
Publicado: (2001)

Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice
por: Khan, Masood Alam, et al.
Publicado: (2021)

Could Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?
por: Mousa, Ayman M, et al.
Publicado: (2021)

Safety and Therapeutic Efficacy of Thymoquinone-Loaded Liposomes against Drug-Sensitive and Drug-Resistant Acinetobacter baumannii
por: Allemailem, Khaled S., et al.
Publicado: (2021)

Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits
por: Mousa, Ayman M., et al.
Publicado: (2022)

Innovative Strategies of Reprogramming Immune System Cells by Targeting CRISPR/Cas9-Based Genome-Editing Tools: A New Era of Cancer Management
por: Allemailem, Khaled S, et al.
Publicado: (2023)

6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity
por: Alsahli, Mohammed A., et al.
Publicado: (2021)

Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics
por: Allemailem, Khaled S, et al.
Publicado: (2021)

Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways
por: Rahmani, Arshad Husain, et al.
Publicado: (2023)

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
por: Almatroudi, Ahmad, et al.
Publicado: (2023)

Evaluation of toxicity of Bilsaan stem bark extracts in Swiss Albino mice
por: Alrumaihi, Faris
Publicado: (2019)

Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
por: Almatroodi, Saleh A., et al.
Publicado: (2020)

Antimicrobial, Immunomodulatory and Anti-Inflammatory Potential of Liposomal Thymoquinone: Implications in the Treatment of Bacterial Pneumonia in Immunocompromised Mice
por: Allemailem, Khaled S., et al.
Publicado: (2021)

Prevalence and associated factors of respiratory allergies in the Kingdom of Saudi Arabia: A cross-sectional investigation, September–December 2020
por: Almatroudi, Ahmad, et al.
Publicado: (2021)

Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential
por: Mitra, Saikat, et al.
Publicado: (2022)

Endoplasmic Reticulum Stress Provocation by Different Nanoparticles: An Innovative Approach to Manage the Cancer and Other Common Diseases
por: Khan, Amjad Ali, et al.
Publicado: (2020)

An In-Silico Investigation to Design a Multi-Epitopes Vaccine against Multi-Drug Resistant Hafnia alvei
por: Alshabrmi, Fahad M., et al.
Publicado: (2022)

Metabolomics study of fibroblasts damaged by UVB and BaP
por: Yang, Xiaoyu, et al.
Publicado: (2021)

Design of a Multi-Epitopes Based Chimeric Vaccine against Enterobacter cloacae Using Pan-Genome and Reverse Vaccinology Approaches
por: Al-Megrin, Wafa Abdullah I., et al.
Publicado: (2022)

Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management
por: Allemailem, Khaled S., et al.
Publicado: (2023)

Role of Cytokines and Chemokines in NSCLC Immune Navigation and Proliferation
por: Ramachandran, Sowmya, et al.
Publicado: (2021)

Novel Strategies for Disrupting Cancer-Cell Functions with Mitochondria-Targeted Antitumor Drug–Loaded Nanoformulations
por: S Allemailem, Khaled, et al.
Publicado: (2021)

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways
por: Almatroodi, Saleh A., et al.
Publicado: (2021)

Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors
por: Rahman, Mohammad A., et al.
Publicado: (2017)

Protective Effects of Diallyl Sulfide and Curcumin Separately against Thallium-Induced Toxicity in Rats
por: Abdel-Daim, Mohamed M., et al.
Publicado: (2015)

Potential Therapeutic Benefits of Honey in Neurological Disorders: The Role of Polyphenols
por: Iftikhar, Arslan, et al.
Publicado: (2022)

Diallyl sulfide protects against dilated cardiomyopathy via inhibition of oxidative stress and apoptosis in mice
por: Pang, Shuo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ema4n62al21jroh2iqahl2l2rl