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A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

Aggregation of human wild-type transthyretin (hTTR), a homo-tetrameric plasma protein, leads to acquired senile systemic amyloidosis (SSA), recently recognised as a major cause of cardiomyopathies in 1–3% older adults. Fragmented hTTR is the standard composition of amyloid deposits in SSA, but the p...

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Detalles Bibliográficos
Autores principales:	Peterle, Daniele, Pontarollo, Giulia, Spada, Stefano, Brun, Paola, Palazzi, Luana, Sokolov, Alexej V., Spolaore, Barbara, Polverino de Laureto, Patrizia, Vasilyev, Vadim B., Castagliuolo, Ignazio, De Filippis, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733459/ https://www.ncbi.nlm.nih.gov/pubmed/33311636 http://dx.doi.org/10.1038/s42003-020-01493-0

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