Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis, necroptosis and inflammation. RIPK1 activation is known to be regulated by its DD-mediated interaction and ubiquitination, though underlying mechanisms remain incompletely understood. Here we show that K627 in human RIP...

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Detalles Bibliográficos
Autores principales: Li, Xingyan, Zhang, Mengmeng, Huang, Xinyue, Liang, Wei, Li, Ganquan, Lu, Xiaojuan, Li, Yanxia, Pan, Heling, Shi, Linyu, Zhu, Hong, Qian, Lihui, Shan, Bing, Yuan, Junying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733462/
https://www.ncbi.nlm.nih.gov/pubmed/33311474
http://dx.doi.org/10.1038/s41467-020-19935-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733462/
https://www.ncbi.nlm.nih.gov/pubmed/33311474
http://dx.doi.org/10.1038/s41467-020-19935-y

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