Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA

The abnormal PI3K/AKT/mTOR pathway is one of the most common genomic abnormalities in breast cancers including triple-negative breast cancer (TNBC), and pharmacologic inhibition of these aberrations has shown activity in TNBC patients. Here, we designed and identified a small-molecule Comp34 that su...

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Detalles Bibliográficos
Autores principales: Hao, Qiongyu, Wang, Piwen, Dutta, Pranabananda, Chung, Seyung, Li, Qun, Wang, Kun, Li, Jieqing, Cao, Wei, Deng, Wenhong, Geng, Qing, Schrode, Katrina, Shaheen, Magda, Wu, Ke, Zhu, Donghui, Chen, Qiao-Hong, Chen, Guanglin, Elshimali, Yahya, Vadgama, Jay, Wu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733521/
https://www.ncbi.nlm.nih.gov/pubmed/33311440
http://dx.doi.org/10.1038/s41419-020-03235-w

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