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The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy

OBJECTIVES: This study aims to research the clinical features of atrial thrombi in patients with nonvalvular atrial fibrillation (AF). METHODS: This study included 191 patients of AF who had atrial thrombi. One hundred and twenty‐eight of them were assigned into nonventricular cardiomyopathy group (...

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Autores principales: Zhang, Hao, Yu, Miao, Xia, Yu, Li, Xiaofeng, Liu, Jun, Fang, Pihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733561/
https://www.ncbi.nlm.nih.gov/pubmed/33335618
http://dx.doi.org/10.1002/joa3.12422
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author Zhang, Hao
Yu, Miao
Xia, Yu
Li, Xiaofeng
Liu, Jun
Fang, Pihua
author_facet Zhang, Hao
Yu, Miao
Xia, Yu
Li, Xiaofeng
Liu, Jun
Fang, Pihua
author_sort Zhang, Hao
collection PubMed
description OBJECTIVES: This study aims to research the clinical features of atrial thrombi in patients with nonvalvular atrial fibrillation (AF). METHODS: This study included 191 patients of AF who had atrial thrombi. One hundred and twenty‐eight of them were assigned into nonventricular cardiomyopathy group (non‐VCM), and the remaining 63 into ventricular cardiomyopathy group (VCM). After atrial thrombi diagnosed, all patients had taken oral anticoagulant therapy. The resolution rates of thrombi within 12 months were compared between the two groups, as well as the locations of thrombi. RESULTS: Of all 191 patients, 161 had thrombi only detected in left atrial appendage (LAA), 20 in both left atrium (LA) and LAA, six in LA only, and four in right atrium only. More patients had thrombi out of LAA in the VCM group than in the non‐VCM group (30.2% vs 8.6%, P < .001). After propensity score matching, the atrial thrombi were resolved faster in the non‐VCM group than in the VCM group (mean time length: 22 ± 2 weeks vs 30 ± 3 weeks, P = .038), and the resolution rate within 12 months was higher in the non‐VCM group than in the VCM group (88.7% vs 61.4%, Log‐rank, P = .038). In Cox proportional hazards model, absence of ventricular cardiomyopathy was an independent predictor for the resolution of atrial thrombus (hazard ratio: 1.76; P = .035). CONCLUSIONS: The patients of atrial fibrillation with ventricular cardiomyopathies have higher incidence of thrombosis in the body of left atrium or right atrium. And the resolution rate was lower in these patients.
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spelling pubmed-77335612020-12-16 The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy Zhang, Hao Yu, Miao Xia, Yu Li, Xiaofeng Liu, Jun Fang, Pihua J Arrhythm Original Articles OBJECTIVES: This study aims to research the clinical features of atrial thrombi in patients with nonvalvular atrial fibrillation (AF). METHODS: This study included 191 patients of AF who had atrial thrombi. One hundred and twenty‐eight of them were assigned into nonventricular cardiomyopathy group (non‐VCM), and the remaining 63 into ventricular cardiomyopathy group (VCM). After atrial thrombi diagnosed, all patients had taken oral anticoagulant therapy. The resolution rates of thrombi within 12 months were compared between the two groups, as well as the locations of thrombi. RESULTS: Of all 191 patients, 161 had thrombi only detected in left atrial appendage (LAA), 20 in both left atrium (LA) and LAA, six in LA only, and four in right atrium only. More patients had thrombi out of LAA in the VCM group than in the non‐VCM group (30.2% vs 8.6%, P < .001). After propensity score matching, the atrial thrombi were resolved faster in the non‐VCM group than in the VCM group (mean time length: 22 ± 2 weeks vs 30 ± 3 weeks, P = .038), and the resolution rate within 12 months was higher in the non‐VCM group than in the VCM group (88.7% vs 61.4%, Log‐rank, P = .038). In Cox proportional hazards model, absence of ventricular cardiomyopathy was an independent predictor for the resolution of atrial thrombus (hazard ratio: 1.76; P = .035). CONCLUSIONS: The patients of atrial fibrillation with ventricular cardiomyopathies have higher incidence of thrombosis in the body of left atrium or right atrium. And the resolution rate was lower in these patients. John Wiley and Sons Inc. 2020-08-29 /pmc/articles/PMC7733561/ /pubmed/33335618 http://dx.doi.org/10.1002/joa3.12422 Text en © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of Japanese Heart Rhythm Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zhang, Hao
Yu, Miao
Xia, Yu
Li, Xiaofeng
Liu, Jun
Fang, Pihua
The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title_full The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title_fullStr The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title_full_unstemmed The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title_short The differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
title_sort differences of atrial thrombus locations and variable response to anticoagulation in nonvalvular atrial fibrillation with ventricular cardiomyopathy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733561/
https://www.ncbi.nlm.nih.gov/pubmed/33335618
http://dx.doi.org/10.1002/joa3.12422
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