Cargando…

Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics

Diagnostic tools play significant roles in the fight against COVID-19 and other pandemics. Existing tests, such as RT-qPCR, have limitations including long assay time, low throughput, inadequate sensitivity, and suboptimal portability. Emerging biosensing technologies hold the promise to develop tes...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Linzhe, Zhang, Guoliang, Liu, Longqi, Li, Zida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733602/
https://www.ncbi.nlm.nih.gov/pubmed/33592734
http://dx.doi.org/10.1016/j.talanta.2020.121986
_version_ 1783622306290991104
author Chen, Linzhe
Zhang, Guoliang
Liu, Longqi
Li, Zida
author_facet Chen, Linzhe
Zhang, Guoliang
Liu, Longqi
Li, Zida
author_sort Chen, Linzhe
collection PubMed
description Diagnostic tools play significant roles in the fight against COVID-19 and other pandemics. Existing tests, such as RT-qPCR, have limitations including long assay time, low throughput, inadequate sensitivity, and suboptimal portability. Emerging biosensing technologies hold the promise to develop tests that are rapid, highly sensitive, and suitable for point-of-care testing, which could significantly facilitate the testing of COVID-19. Despite that, practical applications of such biosensors in pandemics have yet to be achieved. In this review, we consolidate the newly developed diagnostic tools for COVID-19 using emerging biosensing technologies and discuss their application promise. In particular, we present nucleic acid tests and antibody tests of COVID-19 based on both conventional and emerging biosensing methods. We then provide perspectives on the existing challenges and potential solutions.
format Online
Article
Text
id pubmed-7733602
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-77336022020-12-14 Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics Chen, Linzhe Zhang, Guoliang Liu, Longqi Li, Zida Talanta Review Diagnostic tools play significant roles in the fight against COVID-19 and other pandemics. Existing tests, such as RT-qPCR, have limitations including long assay time, low throughput, inadequate sensitivity, and suboptimal portability. Emerging biosensing technologies hold the promise to develop tests that are rapid, highly sensitive, and suitable for point-of-care testing, which could significantly facilitate the testing of COVID-19. Despite that, practical applications of such biosensors in pandemics have yet to be achieved. In this review, we consolidate the newly developed diagnostic tools for COVID-19 using emerging biosensing technologies and discuss their application promise. In particular, we present nucleic acid tests and antibody tests of COVID-19 based on both conventional and emerging biosensing methods. We then provide perspectives on the existing challenges and potential solutions. Elsevier B.V. 2021-04-01 2020-12-13 /pmc/articles/PMC7733602/ /pubmed/33592734 http://dx.doi.org/10.1016/j.talanta.2020.121986 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Chen, Linzhe
Zhang, Guoliang
Liu, Longqi
Li, Zida
Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title_full Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title_fullStr Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title_full_unstemmed Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title_short Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics
title_sort emerging biosensing technologies for improved diagnostics of covid-19 and future pandemics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733602/
https://www.ncbi.nlm.nih.gov/pubmed/33592734
http://dx.doi.org/10.1016/j.talanta.2020.121986
work_keys_str_mv AT chenlinzhe emergingbiosensingtechnologiesforimproveddiagnosticsofcovid19andfuturepandemics
AT zhangguoliang emergingbiosensingtechnologiesforimproveddiagnosticsofcovid19andfuturepandemics
AT liulongqi emergingbiosensingtechnologiesforimproveddiagnosticsofcovid19andfuturepandemics
AT lizida emergingbiosensingtechnologiesforimproveddiagnosticsofcovid19andfuturepandemics