Detection and estimating the blood accumulation volume of brain hemorrhage in a human anatomical skull using a RF single coil

OBJECTIVE: An experimental study for testing a simple robust algorithm on data derived from an electromagnetic radiation device that can detect small changes in the tissue/fluid ratio in a realistic head configuration. METHODS: Changes in the scattering parameters (S(21)) of an inductive coil resulting from injections of chicken blood in the 0–18 ml range into calf brain tissue in a human anatomical skull were measured over a 100–1,000 MHz frequency range. RESULTS: An algorithm that combines amplitude and phase results was found to detect changes in the tissue/fluid ratio with 90% accuracy. An algorithm that estimated the injected blood volume was found to have a 1–4 ml average error. This demonstrates the possibility of the inductive coil-based device to possess a practical ability to detect a change in the tissue/fluid ratio in the head. SIGNIFICANCE: This study is an important step towards the goal of building an inexpensive and safe device that can detect an early brain hemorrhagic stroke.