Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration

A transplanted stem cell’s engagement with a pathologic niche is the first step in its restoring homeostasis to that site. Inflammatory chemokines are constitutively produced in such a niche; their binding to receptors on the stem cell helps direct that cell’s “pathotropism.” Neural stem cells (NSCs...

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Detalles Bibliográficos
Autores principales: Lee, Jean-Pyo, Zhang, Runquan, Yan, Maocai, Duggineni, Srinivas, Wakeman, Dustin R., Niles, Walter L., Feng, Yongmei, Chen, Justin, Hamblin, Milton H., Han, Edward B., Gonzalez, Rodolfo, Fang, Xiao, Zhu, Yinsong, Wang, Juan, Xu, Yan, Wenger, David A., Seyfried, Thomas N., An, Jing, Sidman, Richard L., Huang, Ziwei, Snyder, Evan Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733796/
https://www.ncbi.nlm.nih.gov/pubmed/33219123
http://dx.doi.org/10.1073/pnas.1911444117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733796/
https://www.ncbi.nlm.nih.gov/pubmed/33219123
http://dx.doi.org/10.1073/pnas.1911444117

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