Cargando…

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress

Recessive loss-of-function mutations in ATP13A2 (PARK9) are associated with a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD). We recently revealed that the late endo-lysosomal transporter ATP13A2 pumps polyamines like spermine into the cytosol, whereas ATP13A2 dysfunctio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vrijsen, Stephanie, Besora-Casals, Laura, van Veen, Sarah, Zielich, Jeffrey, Van den Haute, Chris, Hamouda, Norin Nabil, Fischer, Christian, Ghesquière, Bart, Tournev, Ivailo, Agostinis, Patrizia, Baekelandt, Veerle, Eggermont, Jan, Lambie, Eric, Martin, Shaun, Vangheluwe, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2020
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733819/ https://www.ncbi.nlm.nih.gov/pubmed/33229544 http://dx.doi.org/10.1073/pnas.1922342117

Ejemplares similares

ATP13A4 Upregulation Drives the Elevated Polyamine Transport System in the Breast Cancer Cell Line MCF7
por: van Veen, Sarah, et al.
Publicado: (2023)

ATP13A3 is a major component of the enigmatic mammalian polyamine transport system
por: Hamouda, Norin Nabil, et al.
Publicado: (2020)

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
por: Martin, Shaun, et al.
Publicado: (2016)

Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export
por: Martin, Shaun, et al.
Publicado: (2020)

ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization
por: Si, Jianmin, et al.
Publicado: (2021)

Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System
por: Houdou, Marine, et al.
Publicado: (2023)

Parkinson disease related ATP13A2 evolved early in animal evolution
por: Sørensen, Danny Mollerup, et al.
Publicado: (2018)

Mutant LRRK2 exacerbates immune response and neurodegeneration in a chronic model of experimental colitis
por: Cabezudo, Diego, et al.
Publicado: (2023)

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity
por: Lobbestael, Evy, et al.
Publicado: (2020)

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites
por: Vrijsen, Stephanie, et al.
Publicado: (2022)

Rapamycin-induced protein dimerization as a tool for C. elegans research
por: Mangal, Sriyash, et al.
Publicado: (2018)

Establishment of a CRISPR/Cas9-based strategy for inducible protein dimerization
por: Zielich, Jeffrey, et al.
Publicado: (2018)

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks
por: Pulizzi, Rocco, et al.
Publicado: (2016)

Long-Term Fate Mapping Using Conditional Lentiviral Vectors Reveals a Continuous Contribution of Radial Glia-Like Cells to Adult Hippocampal Neurogenesis in Mice
por: Aelvoet, Sarah-Ann, et al.
Publicado: (2015)

Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens
por: Lambie, Eric J., et al.
Publicado: (2015)

Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson’s disease
por: Torre-Muruzabal, Teresa, et al.
Publicado: (2019)

IL-10 regulates adult neurogenesis by modulating ERK and STAT3 activity
por: Pereira, Leticia, et al.
Publicado: (2015)

Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss
por: Scheyltjens, Isabelle, et al.
Publicado: (2018)

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine
por: Li, Zhiling, et al.
Publicado: (2019)

Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration
por: Van Rompuy, Anne-Sophie, et al.
Publicado: (2015)

Axonal neuropathy with neuromyotonia: there is a HINT
por: Peeters, Kristien, et al.
Publicado: (2017)

Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans
por: Zielich, Jeffrey, et al.
Publicado: (2018)

Immunohistochemical detection of transgene expression in the brain using small epitope tags
por: Lobbestael, Evy, et al.
Publicado: (2010)

Phenotypic Differences of Glu89Gln Genotype in ATTR Amyloidosis From Endemic Loci: Update From THAOS
por: Gentile, Luca, et al.
Publicado: (2021)

Tackling Glaucoma from within the Brain: An Unfortunate Interplay of BDNF and TrkB
por: Dekeyster, Eline, et al.
Publicado: (2015)

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
por: Oliveras-Salvá, Marusela, et al.
Publicado: (2013)

The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies
por: Van der Perren, Anke, et al.
Publicado: (2020)

Cognitive Impairment and Brain Imaging Characteristics of Patients with Congenital Cataracts, Facial Dysmorphism, Neuropathy Syndrome
por: Chamova, Teodora, et al.
Publicado: (2015)

Peripheral myelin protein 2 – a novel cluster of mutations causing Charcot-Marie-Tooth neuropathy
por: Palaima, Paulius, et al.
Publicado: (2019)

An integrated multi-electrode-optrode array for in vitro optogenetics
por: Welkenhuysen, Marleen, et al.
Publicado: (2016)

EndoTrainer: a novel hybrid training platform for endoscopic surgery
por: Hernansanz, Albert, et al.
Publicado: (2023)

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Screening for hereditary transthyretin amyloidosis in Bulgaria
por: Nakov, Radislav, et al.
Publicado: (2021)

Practical Synthesis of Polyamine Succinamides and Branched Polyamines
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2022)

A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity
por: Stevens, Latoya, et al.
Publicado: (2020)

Linking Neuroinflammation and Neurodegeneration in Parkinson's Disease
por: Gelders, Géraldine, et al.
Publicado: (2018)

Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination
por: Maheshwari, Anurag, et al.
Publicado: (2013)

Editorial: Polyamines and longevity - role of polyamine in plant survival
por: Parrotta, Luigi, et al.
Publicado: (2023)

Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition
por: Loll, Bernhard, et al.
Publicado: (2009)

Glu89Gln transthyretin-related amyloidosis in Italy and Bulgaria: does geographic area influence phenotype beyond the shared mutation?
por: Gagliardi, Christian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gp4p7575bddt610vip3cj1oubb