A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction

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Progressive remodeling of the heart, resulting in cardiomyocyte (CM) loss and increased inflammation, fibrosis, and a progressive decrease in cardiac function, are hallmarks of myocardial infarction (MI)-induced heart failure. We show that MCB-613, a potent small molecule stimulator of steroid recep...

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Detalles Bibliográficos
Autores principales: Mullany, Lisa K., Rohira, Aarti D., Leach, John P., Kim, Jong H., Monroe, Tanner O., Ortiz, Andrea R., Stork, Brittany, Gaber, M. Waleed, Sarkar, Poonam, Sikora, Andrew G., Rosengart, Todd K., York, Brian, Song, Yongcheng, Dacso, Clifford C., Lonard, David M., Martin, James F., O’Malley, Bert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733826/
https://www.ncbi.nlm.nih.gov/pubmed/33229578
http://dx.doi.org/10.1073/pnas.2011614117
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