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The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells

Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle...

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Autores principales: Ghafouri-Fard, Soudeh, Shoorei, Hamed, Anamag, Farhad Tondro, Taheri, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734207/
https://www.ncbi.nlm.nih.gov/pubmed/33330110
http://dx.doi.org/10.3389/fonc.2020.608975
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author Ghafouri-Fard, Soudeh
Shoorei, Hamed
Anamag, Farhad Tondro
Taheri, Mohammad
author_facet Ghafouri-Fard, Soudeh
Shoorei, Hamed
Anamag, Farhad Tondro
Taheri, Mohammad
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies.
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spelling pubmed-77342072020-12-15 The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells Ghafouri-Fard, Soudeh Shoorei, Hamed Anamag, Farhad Tondro Taheri, Mohammad Front Oncol Oncology Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies. Frontiers Media S.A. 2020-11-30 /pmc/articles/PMC7734207/ /pubmed/33330110 http://dx.doi.org/10.3389/fonc.2020.608975 Text en Copyright © 2020 Ghafouri-Fard, Shoorei, Anamag and Taheri http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Shoorei, Hamed
Anamag, Farhad Tondro
Taheri, Mohammad
The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title_full The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title_fullStr The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title_full_unstemmed The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title_short The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
title_sort role of non-coding rnas in controlling cell cycle related proteins in cancer cells
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734207/
https://www.ncbi.nlm.nih.gov/pubmed/33330110
http://dx.doi.org/10.3389/fonc.2020.608975
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