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The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells
Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734207/ https://www.ncbi.nlm.nih.gov/pubmed/33330110 http://dx.doi.org/10.3389/fonc.2020.608975 |
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author | Ghafouri-Fard, Soudeh Shoorei, Hamed Anamag, Farhad Tondro Taheri, Mohammad |
author_facet | Ghafouri-Fard, Soudeh Shoorei, Hamed Anamag, Farhad Tondro Taheri, Mohammad |
author_sort | Ghafouri-Fard, Soudeh |
collection | PubMed |
description | Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies. |
format | Online Article Text |
id | pubmed-7734207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77342072020-12-15 The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells Ghafouri-Fard, Soudeh Shoorei, Hamed Anamag, Farhad Tondro Taheri, Mohammad Front Oncol Oncology Cell cycle is regulated by a number of proteins namely cyclin-dependent kinases (CDKs) and their associated cyclins which bind with and activate CDKs in a phase specific manner. Additionally, several transcription factors (TFs) such as E2F and p53 and numerous signaling pathways regulate cell cycle progression. Recent studies have accentuated the role of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the regulation of cell cycle. Both lncRNAs and miRNAs interact with TFs participating in the regulation of cell cycle transition. Dysregulation of cell cycle regulatory miRNAs and lncRNAs results in human disorders particularly cancers. Understanding the role of lncRNAs, miRNAs, and TFs in the regulation of cell cycle would pave the way for design of anticancer therapies which intervene with the cell cycle progression. In the current review, we describe the role of lncRNAs and miRNAs in the regulation of cell cycle and their association with human malignancies. Frontiers Media S.A. 2020-11-30 /pmc/articles/PMC7734207/ /pubmed/33330110 http://dx.doi.org/10.3389/fonc.2020.608975 Text en Copyright © 2020 Ghafouri-Fard, Shoorei, Anamag and Taheri http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Ghafouri-Fard, Soudeh Shoorei, Hamed Anamag, Farhad Tondro Taheri, Mohammad The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title | The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title_full | The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title_fullStr | The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title_full_unstemmed | The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title_short | The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells |
title_sort | role of non-coding rnas in controlling cell cycle related proteins in cancer cells |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734207/ https://www.ncbi.nlm.nih.gov/pubmed/33330110 http://dx.doi.org/10.3389/fonc.2020.608975 |
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