Development and applications of artificial symmetrical proteins

Since the determination of the first molecular models of proteins there has been interest in creating proteins artificially, but such methods have only become widely successful in the last decade. Gradual improvements over a long period of time have now yielded numerous examples of non-natural prote...

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Detalles Bibliográficos
Autores principales: Vrancken, Jeroen P.M., Tame, Jeremy R.H., Voet, Arnout R.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734218/
https://www.ncbi.nlm.nih.gov/pubmed/33335692
http://dx.doi.org/10.1016/j.csbj.2020.10.040
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author Vrancken, Jeroen P.M.
Tame, Jeremy R.H.
Voet, Arnout R.D.
author_facet Vrancken, Jeroen P.M.
Tame, Jeremy R.H.
Voet, Arnout R.D.
author_sort Vrancken, Jeroen P.M.
collection PubMed
description Since the determination of the first molecular models of proteins there has been interest in creating proteins artificially, but such methods have only become widely successful in the last decade. Gradual improvements over a long period of time have now yielded numerous examples of non-natural proteins, many of which are built from repeated elements. In this review we discuss the design of such symmetrical proteins and their various applications in chemistry and medicine.
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spelling pubmed-77342182020-12-16 Development and applications of artificial symmetrical proteins Vrancken, Jeroen P.M. Tame, Jeremy R.H. Voet, Arnout R.D. Comput Struct Biotechnol J Review Article Since the determination of the first molecular models of proteins there has been interest in creating proteins artificially, but such methods have only become widely successful in the last decade. Gradual improvements over a long period of time have now yielded numerous examples of non-natural proteins, many of which are built from repeated elements. In this review we discuss the design of such symmetrical proteins and their various applications in chemistry and medicine. Research Network of Computational and Structural Biotechnology 2020-11-27 /pmc/articles/PMC7734218/ /pubmed/33335692 http://dx.doi.org/10.1016/j.csbj.2020.10.040 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Vrancken, Jeroen P.M.
Tame, Jeremy R.H.
Voet, Arnout R.D.
Development and applications of artificial symmetrical proteins
title Development and applications of artificial symmetrical proteins
title_full Development and applications of artificial symmetrical proteins
title_fullStr Development and applications of artificial symmetrical proteins
title_full_unstemmed Development and applications of artificial symmetrical proteins
title_short Development and applications of artificial symmetrical proteins
title_sort development and applications of artificial symmetrical proteins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734218/
https://www.ncbi.nlm.nih.gov/pubmed/33335692
http://dx.doi.org/10.1016/j.csbj.2020.10.040
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