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Perampanel Add-on to Standard Radiochemotherapy in vivo Promotes Neuroprotection in a Rodent F98 Glioma Model

An abnormal glutamate signaling of glioblastoma may contribute to both tumor progression and the generation of glioma-associated epileptic seizures. We hypothesized that the AMPA receptor antagonist perampanel (PER) could attenuate tumor growth and epileptic events. F98 glioma cells, grown orthotopi...

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Detalles Bibliográficos
Autores principales:	Lange, Falko, Hartung, Jens, Liebelt, Clara, Boisserée, Julius, Resch, Tobias, Porath, Katrin, Hörnschemeyer, Julia, Reichart, Gesine, Sellmann, Tina, Neubert, Valentin, Kriesen, Stephan, Hildebrandt, Guido, Schültke, Elisabeth, Köhling, Rüdiger, Kirschstein, Timo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734300/ https://www.ncbi.nlm.nih.gov/pubmed/33328869 http://dx.doi.org/10.3389/fnins.2020.598266

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