Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications

In recent years, the number of diabetic patients has rapidly increased. Diabetic vascular complications seriously affect people’s quality of life. Studies found that endothelial dysfunction precedes the vascular complications of diabetes. Endothelial dysfunction is related to glycocalyx degradation...

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Detalles Bibliográficos
Autores principales: Li, Zhi, Wu, Ning, Wang, Jing, Zhang, Quanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734331/
https://www.ncbi.nlm.nih.gov/pubmed/33328998
http://dx.doi.org/10.3389/fphar.2020.590614
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author Li, Zhi
Wu, Ning
Wang, Jing
Zhang, Quanbin
author_facet Li, Zhi
Wu, Ning
Wang, Jing
Zhang, Quanbin
author_sort Li, Zhi
collection PubMed
description In recent years, the number of diabetic patients has rapidly increased. Diabetic vascular complications seriously affect people’s quality of life. Studies found that endothelial dysfunction precedes the vascular complications of diabetes. Endothelial dysfunction is related to glycocalyx degradation on the surface of blood vessels. Heparanase (HPSE), matrix metalloproteinase (MMP), hyaluronidase (HYAL), hyaluronic acid synthase (HAS), and neuraminidase (NEU) are related to glycocalyx degradation. Therefore, we reviewed the relationship between endothelial dysfunction and the vascular complications of diabetes from the perspective of enzymes.
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spelling pubmed-77343312020-12-15 Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications Li, Zhi Wu, Ning Wang, Jing Zhang, Quanbin Front Pharmacol Pharmacology In recent years, the number of diabetic patients has rapidly increased. Diabetic vascular complications seriously affect people’s quality of life. Studies found that endothelial dysfunction precedes the vascular complications of diabetes. Endothelial dysfunction is related to glycocalyx degradation on the surface of blood vessels. Heparanase (HPSE), matrix metalloproteinase (MMP), hyaluronidase (HYAL), hyaluronic acid synthase (HAS), and neuraminidase (NEU) are related to glycocalyx degradation. Therefore, we reviewed the relationship between endothelial dysfunction and the vascular complications of diabetes from the perspective of enzymes. Frontiers Media S.A. 2020-11-30 /pmc/articles/PMC7734331/ /pubmed/33328998 http://dx.doi.org/10.3389/fphar.2020.590614 Text en Copyright © 2020 Li, Wu, Wang and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Zhi
Wu, Ning
Wang, Jing
Zhang, Quanbin
Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title_full Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title_fullStr Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title_full_unstemmed Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title_short Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications
title_sort roles of endovascular calyx related enzymes in endothelial dysfunction and diabetic vascular complications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734331/
https://www.ncbi.nlm.nih.gov/pubmed/33328998
http://dx.doi.org/10.3389/fphar.2020.590614
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