Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome

Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6.1 subunits, respectively, of KATP channels. Pathological consequences of CS have been reported for cardiac and smooth muscle cel...

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Detalles Bibliográficos
Autores principales: Scala, Rosa, Maqoud, Fatima, Zizzo, Nicola, Mele, Antonietta, Camerino, Giulia Maria, Zito, Francesco Alfredo, Ranieri, Girolamo, McClenaghan, Conor, Harter, Theresa M., Nichols, Colin G., Tricarico, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734337/
https://www.ncbi.nlm.nih.gov/pubmed/33329006
http://dx.doi.org/10.3389/fphar.2020.604885

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