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Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease
Clinically amyopathic dermatomyositis (CADM) with anti‐melanoma differentiation‐associated gene 5 antibody is associated with rapidly progressive interstitial lung disease (RP‐ILD) which results in up to 50% mortality, especially within six months of diagnosis. However, limited data are available on...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734424/ https://www.ncbi.nlm.nih.gov/pubmed/33343905 http://dx.doi.org/10.1002/rcr2.701 |
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author | Kaenmuang, Punchalee Navasakulpong, Asma |
author_facet | Kaenmuang, Punchalee Navasakulpong, Asma |
author_sort | Kaenmuang, Punchalee |
collection | PubMed |
description | Clinically amyopathic dermatomyositis (CADM) with anti‐melanoma differentiation‐associated gene 5 antibody is associated with rapidly progressive interstitial lung disease (RP‐ILD) which results in up to 50% mortality, especially within six months of diagnosis. However, limited data are available on this disease. This is the first case series of six patients in Thailand diagnosed with CADM with ILD. All patients presented with respiratory symptoms, such as progressive dyspnoea, dyspnoea on exertion, or cough. High‐resolution computed tomography of the chest showed predominantly subpleural and peripheral consolidation in both lower lungs. Four patients had RP‐ILD and three of the RP‐ILD patients died within seven weeks of diagnosis. These cases illustrate the clinical characteristics, chest imaging, treatments, and clinical outcomes of the patients diagnosed with CADM and ILD. |
format | Online Article Text |
id | pubmed-7734424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-77344242020-12-18 Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease Kaenmuang, Punchalee Navasakulpong, Asma Respirol Case Rep Case Series Clinically amyopathic dermatomyositis (CADM) with anti‐melanoma differentiation‐associated gene 5 antibody is associated with rapidly progressive interstitial lung disease (RP‐ILD) which results in up to 50% mortality, especially within six months of diagnosis. However, limited data are available on this disease. This is the first case series of six patients in Thailand diagnosed with CADM with ILD. All patients presented with respiratory symptoms, such as progressive dyspnoea, dyspnoea on exertion, or cough. High‐resolution computed tomography of the chest showed predominantly subpleural and peripheral consolidation in both lower lungs. Four patients had RP‐ILD and three of the RP‐ILD patients died within seven weeks of diagnosis. These cases illustrate the clinical characteristics, chest imaging, treatments, and clinical outcomes of the patients diagnosed with CADM and ILD. John Wiley & Sons, Ltd 2020-12-14 /pmc/articles/PMC7734424/ /pubmed/33343905 http://dx.doi.org/10.1002/rcr2.701 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Series Kaenmuang, Punchalee Navasakulpong, Asma Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title | Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title_full | Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title_fullStr | Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title_full_unstemmed | Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title_short | Clinical characteristics of anti‐MDA5 antibody‐positive interstitial lung disease |
title_sort | clinical characteristics of anti‐mda5 antibody‐positive interstitial lung disease |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734424/ https://www.ncbi.nlm.nih.gov/pubmed/33343905 http://dx.doi.org/10.1002/rcr2.701 |
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