Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin challenge

Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and SEB were expressed in pET28a prokaryotic plasmids. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in mSEB-s...

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Detalles Bibliográficos
Autores principales: Xiong, Zhile, Mai, Jialiang, Li, Fei, Liang, Bingshao, Yao, Shuwen, Liang, Zhuwei, Zhang, Chao, Gao, Fei, Ai, Xiaolan, Wang, Jielin, Long, Yan, Yang, Min, Gong, Sitang, Zhou, Zhenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734462/
https://www.ncbi.nlm.nih.gov/pubmed/33315153
http://dx.doi.org/10.1186/s13568-020-01152-x

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