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A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ

In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells e...

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Detalles Bibliográficos
Autores principales: Tomeu, Antonio J., Salguero, Alberto G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734501/
https://www.ncbi.nlm.nih.gov/pubmed/32267247
http://dx.doi.org/10.1515/jib-2019-0070
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author Tomeu, Antonio J.
Salguero, Alberto G.
author_facet Tomeu, Antonio J.
Salguero, Alberto G.
author_sort Tomeu, Antonio J.
collection PubMed
description In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells exert, under a wide range of parameters. There are some proposals in the literature that parallelize the CPM; in all cases, either lock-based techniques or other techniques that require large amounts of information to be disseminated among parallel tasks are used to preserve data coherence. In both cases, computational performance is limited. This work proposes an alternative approach for the parallelization of the model that uses transactional memory to maintain the coherence of the information. A Java implementation has been applied to the simulation of the ductal adenocarcinoma of breast in situ (DCIS). Times and speedups of the simulated execution of the model on the cluster of our university are analyzed. The results show a good speedup.
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spelling pubmed-77345012020-12-22 A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ Tomeu, Antonio J. Salguero, Alberto G. J Integr Bioinform Research Article In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells exert, under a wide range of parameters. There are some proposals in the literature that parallelize the CPM; in all cases, either lock-based techniques or other techniques that require large amounts of information to be disseminated among parallel tasks are used to preserve data coherence. In both cases, computational performance is limited. This work proposes an alternative approach for the parallelization of the model that uses transactional memory to maintain the coherence of the information. A Java implementation has been applied to the simulation of the ductal adenocarcinoma of breast in situ (DCIS). Times and speedups of the simulated execution of the model on the cluster of our university are analyzed. The results show a good speedup. De Gruyter 2020-04-07 /pmc/articles/PMC7734501/ /pubmed/32267247 http://dx.doi.org/10.1515/jib-2019-0070 Text en © 2020, Antonio J. Tomeu and Alberto G. Salguero published by Walter de Gruyter GmbH, Berlin/Boston http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License.
spellingShingle Research Article
Tomeu, Antonio J.
Salguero, Alberto G.
A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title_full A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title_fullStr A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title_full_unstemmed A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title_short A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
title_sort lock free approach to parallelize the cellular potts model: application to ductal carcinoma in situ
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734501/
https://www.ncbi.nlm.nih.gov/pubmed/32267247
http://dx.doi.org/10.1515/jib-2019-0070
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