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A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ
In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734501/ https://www.ncbi.nlm.nih.gov/pubmed/32267247 http://dx.doi.org/10.1515/jib-2019-0070 |
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author | Tomeu, Antonio J. Salguero, Alberto G. |
author_facet | Tomeu, Antonio J. Salguero, Alberto G. |
author_sort | Tomeu, Antonio J. |
collection | PubMed |
description | In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells exert, under a wide range of parameters. There are some proposals in the literature that parallelize the CPM; in all cases, either lock-based techniques or other techniques that require large amounts of information to be disseminated among parallel tasks are used to preserve data coherence. In both cases, computational performance is limited. This work proposes an alternative approach for the parallelization of the model that uses transactional memory to maintain the coherence of the information. A Java implementation has been applied to the simulation of the ductal adenocarcinoma of breast in situ (DCIS). Times and speedups of the simulated execution of the model on the cluster of our university are analyzed. The results show a good speedup. |
format | Online Article Text |
id | pubmed-7734501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-77345012020-12-22 A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ Tomeu, Antonio J. Salguero, Alberto G. J Integr Bioinform Research Article In the field of computational biology, in order to simulate multiscale biological systems, the Cellular Potts Model (CPM) has been used, which determines the actions that simulated cells can perform by determining a hamiltonian of energy that takes into account the influence that neighboring cells exert, under a wide range of parameters. There are some proposals in the literature that parallelize the CPM; in all cases, either lock-based techniques or other techniques that require large amounts of information to be disseminated among parallel tasks are used to preserve data coherence. In both cases, computational performance is limited. This work proposes an alternative approach for the parallelization of the model that uses transactional memory to maintain the coherence of the information. A Java implementation has been applied to the simulation of the ductal adenocarcinoma of breast in situ (DCIS). Times and speedups of the simulated execution of the model on the cluster of our university are analyzed. The results show a good speedup. De Gruyter 2020-04-07 /pmc/articles/PMC7734501/ /pubmed/32267247 http://dx.doi.org/10.1515/jib-2019-0070 Text en © 2020, Antonio J. Tomeu and Alberto G. Salguero published by Walter de Gruyter GmbH, Berlin/Boston http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 Public License. |
spellingShingle | Research Article Tomeu, Antonio J. Salguero, Alberto G. A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title | A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title_full | A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title_fullStr | A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title_full_unstemmed | A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title_short | A Lock Free Approach To Parallelize The Cellular Potts Model: Application To Ductal Carcinoma In Situ |
title_sort | lock free approach to parallelize the cellular potts model: application to ductal carcinoma in situ |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734501/ https://www.ncbi.nlm.nih.gov/pubmed/32267247 http://dx.doi.org/10.1515/jib-2019-0070 |
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