Cargando…

Neuroprotective Effects of Higenamine Against the Alzheimer’s Disease Via Amelioration of Cognitive Impairment, Aβ Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway

The present investigation was envisaged to elucidate the neuroprotective effect of Higenamine (HGN) against aluminum chloride (AlCl(3)) triggered experimental Alzheimer’s disease (AD) rat model. Thirty-six male albino Wister rats were randomized and divided in 6 groups and subjected to experimentati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Xiaona, Du, Wanliang, Zhang, Yun, Wang, Hui, He, Maolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734528/ https://www.ncbi.nlm.nih.gov/pubmed/33354171 http://dx.doi.org/10.1177/1559325820972205

Ejemplares similares

β(2)‐Adrenoceptor agonist activity of higenamine
por: Hudzik, Thomas J., et al.
Publicado: (2021)

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice
por: Peng, Yan, et al.
Publicado: (2022)

PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3β/Akt signaling pathway in mouse
por: Zhou, Xing-qin, et al.
Publicado: (2018)

Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells
por: Bai, Xiaoliang, et al.
Publicado: (2019)

AKT/GSK3β Signaling in Glioblastoma
por: Majewska, Ewelina, et al.
Publicado: (2016)

Influence of racemic higenamine on the sinus node
por: YU, FENGXIA, et al.
Publicado: (2013)

Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway
por: LIU, XINYU, et al.
Publicado: (2015)

Intranasal Oxytocin Attenuates Cognitive Impairment, β-Amyloid Burden and Tau Deposition in Female Rats with Alzheimer’s Disease: Interplay of ERK1/2/GSK3β/Caspase-3
por: El-Ganainy, Samar O., et al.
Publicado: (2022)

Neuroprotection Against Parkinson’s Disease Through the Activation of Akt/GSK3β Signaling Pathway by Tovophyllin A
por: Huang, Yanjun, et al.
Publicado: (2020)

GSK3β Inhibition Ameliorates Atherosclerotic Calcification
por: Cai, Xinjiang, et al.
Publicado: (2023)

Chinese Medicine, Succinum, Ameliorates Cognitive Impairment of Carotid Artery Ligation Rats and Inhibits Apoptosis of HT22 Hippocampal Cells via Regulation of the GSK3β/β-Catenin Pathway
por: Wei, Chongqi, et al.
Publicado: (2022)

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
por: Kitagishi, Yasuko, et al.
Publicado: (2014)

The Antioxidant Capability of Higenamine: Insights from Theory
por: Romeo, Isabella, et al.
Publicado: (2020)

Higenamine in Plants as a Source of Unintentional Doping
por: Rangelov Kozhuharov, Vanya, et al.
Publicado: (2022)

Pioglitazone ameliorates Aβ42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3β activation
por: Yang, Sisi, et al.
Publicado: (2017)

Higenamine Attenuates Doxorubicin-Induced Cardiac Remodeling and Myocyte Apoptosis by Suppressing AMPK Activation
por: Jin, Cuiliu, et al.
Publicado: (2022)

The seed of Litchi chinensis fraction ameliorates hippocampal neuronal injury in an Aβ(25-35)-induced Alzheimer’s disease rat model via the AKT/GSK-3β pathway
por: Sun, Yueshan, et al.
Publicado: (2019)

Cryptotanshinone Ameliorates Doxorubicin-Induced Cardiotoxicity by Targeting Akt-GSK-3β-mPTP Pathway In Vitro
por: Wang, Xiaoping, et al.
Publicado: (2021)

Astragaloside IV Ameliorates Streptozotocin Induced Pancreatic β-Cell Apoptosis and Dysfunction Through SIRT1/P53 and Akt/GSK3β/Nrf2 Signaling Pathways
por: Lin, Yuqiong, et al.
Publicado: (2022)

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease
por: Sofola, Oyinkan, et al.
Publicado: (2010)

Higenamine Combined with [6]-Gingerol Suppresses Doxorubicin-Triggered Oxidative Stress and Apoptosis in Cardiomyocytes via Upregulation of PI3K/Akt Pathway
por: Chen, Yan-Ling, et al.
Publicado: (2013)

The neuroprotection of cerebrolysin after spontaneous intracerebral hemorrhage through regulates necroptosis via Akt/ GSK3β signaling pathway
por: Tao, Yunna, et al.
Publicado: (2021)

Targeting Akt by SC66 triggers GSK-3β mediated apoptosis in colon cancer therapy
por: Liu, Yeying, et al.
Publicado: (2019)

Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway
por: Prema, Asokan, et al.
Publicado: (2016)

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway
por: Huang, Qianqian, et al.
Publicado: (2022)

pH Effect and Chemical Mechanisms of Antioxidant Higenamine
por: Xie, Yulu, et al.
Publicado: (2018)

Role of Higenamine in Heart Diseases: A Mini-Review
por: Wen, Jianxia, et al.
Publicado: (2022)

TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model
por: Wang, Xiufen, et al.
Publicado: (2022)

Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways
por: Ibrahim, Weam W., et al.
Publicado: (2019)

Duloxetine by Modulating the Akt/GSK3 Signaling Pathways Has Neuroprotective Effects against Methamphetamine-Induced Neurodegeneration and Cognition Impairment in Rats
por: Rahimi Borumand, Mehrasa, et al.
Publicado: (2019)

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
por: Nadeem, Muhammad Shahid, et al.
Publicado: (2021)

Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease
por: Yang, Wen, et al.
Publicado: (2020)

Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling
por: Hu, Yuan-Shih, et al.
Publicado: (2013)

Dec1 Deficiency Ameliorates Pulmonary Fibrosis Through the PI3K/AKT/GSK-3β/β-Catenin Integrated Signaling Pathway
por: Hu, Xingxing, et al.
Publicado: (2022)

Correction: Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease
por: Sofola, Oyinkan, et al.
Publicado: (2012)

Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway
por: Zhang, Wei, et al.
Publicado: (2016)

Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease
por: Bian, Yaqi, et al.
Publicado: (2021)

Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease
por: Wang, Cunli, et al.
Publicado: (2023)

Hyperbaric oxygen therapy attenuates neuronal apoptosis induced by traumatic brain injury via Akt/GSK3β/β-catenin pathway
por: He, Hui, et al.
Publicado: (2019)

Peroxiredoxin I deficiency increases pancreatic β-cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway
por: Jin, Mei-Hua, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j85a6r1f0nv73lksu8uh4lnqj7