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Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome
There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the fi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734626/ https://www.ncbi.nlm.nih.gov/pubmed/32885904 http://dx.doi.org/10.1002/pbc.28693 |
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| author | Diorio, Caroline Anderson, Elizabeth M. McNerney, Kevin O. Goodwin, Eileen C. Chase, Julie C. Bolton, Marcus J. Arevalo, Claudia P. Weirick, Madison E. Gouma, Sigrid Vella, Laura A. Henrickson, Sarah E. Chiotos, Kathleen Fitzgerald, Julie C. Kilbaugh, Todd J. Odom John, Audrey R. Blatz, Allison M. Lambert, Michele P. Sullivan, Kathleen E. Tartaglione, Margaret R. Zambrano, Danielle Martin, Meghan Lee, Jessica H. Young, Pampee Friedman, David Sesok-Pizzini, Deborah A. Hensley, Scott E. Behrens, Edward M. Bassiri, Hamid Teachey, David T. |
| author_facet | Diorio, Caroline Anderson, Elizabeth M. McNerney, Kevin O. Goodwin, Eileen C. Chase, Julie C. Bolton, Marcus J. Arevalo, Claudia P. Weirick, Madison E. Gouma, Sigrid Vella, Laura A. Henrickson, Sarah E. Chiotos, Kathleen Fitzgerald, Julie C. Kilbaugh, Todd J. Odom John, Audrey R. Blatz, Allison M. Lambert, Michele P. Sullivan, Kathleen E. Tartaglione, Margaret R. Zambrano, Danielle Martin, Meghan Lee, Jessica H. Young, Pampee Friedman, David Sesok-Pizzini, Deborah A. Hensley, Scott E. Behrens, Edward M. Bassiri, Hamid Teachey, David T. |
| author_sort | Diorio, Caroline |
| collection | PubMed |
| description | There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed. |
| format | Online Article Text |
| id | pubmed-7734626 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77346262021-11-01 Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome Diorio, Caroline Anderson, Elizabeth M. McNerney, Kevin O. Goodwin, Eileen C. Chase, Julie C. Bolton, Marcus J. Arevalo, Claudia P. Weirick, Madison E. Gouma, Sigrid Vella, Laura A. Henrickson, Sarah E. Chiotos, Kathleen Fitzgerald, Julie C. Kilbaugh, Todd J. Odom John, Audrey R. Blatz, Allison M. Lambert, Michele P. Sullivan, Kathleen E. Tartaglione, Margaret R. Zambrano, Danielle Martin, Meghan Lee, Jessica H. Young, Pampee Friedman, David Sesok-Pizzini, Deborah A. Hensley, Scott E. Behrens, Edward M. Bassiri, Hamid Teachey, David T. Pediatr Blood Cancer Article There are no proven safe and effective therapies for children who develop life-threatening complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma (CP) has demonstrated potential benefit in adults with SARS-CoV-2, but has theoretical risks.We present the first report of CP in children with life-threatening coronavirus disease 2019 (COVID-19), providing data on four pediatric patients with acute respiratory distress syndrome. We measured donor antibody levels and recipient antibody response prior to and following CP infusion. Infusion of CP was not associated with antibody-dependent enhancement (ADE) and did not suppress endogenous antibody response. We found CP was safe and possibly efficacious. Randomized pediatric trials are needed. 2020-09-04 2020-11 /pmc/articles/PMC7734626/ /pubmed/32885904 http://dx.doi.org/10.1002/pbc.28693 Text en This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Article Diorio, Caroline Anderson, Elizabeth M. McNerney, Kevin O. Goodwin, Eileen C. Chase, Julie C. Bolton, Marcus J. Arevalo, Claudia P. Weirick, Madison E. Gouma, Sigrid Vella, Laura A. Henrickson, Sarah E. Chiotos, Kathleen Fitzgerald, Julie C. Kilbaugh, Todd J. Odom John, Audrey R. Blatz, Allison M. Lambert, Michele P. Sullivan, Kathleen E. Tartaglione, Margaret R. Zambrano, Danielle Martin, Meghan Lee, Jessica H. Young, Pampee Friedman, David Sesok-Pizzini, Deborah A. Hensley, Scott E. Behrens, Edward M. Bassiri, Hamid Teachey, David T. Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title | Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title_full | Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title_fullStr | Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title_full_unstemmed | Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title_short | Convalescent plasma for pediatric patients with SARS-CoV-2-associated acute respiratory distress syndrome |
| title_sort | convalescent plasma for pediatric patients with sars-cov-2-associated acute respiratory distress syndrome |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734626/ https://www.ncbi.nlm.nih.gov/pubmed/32885904 http://dx.doi.org/10.1002/pbc.28693 |
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