Cargando…

Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation

[Image: see text] The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Among the main limitations for this compound, its lo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorst, Andrea, Berg, Regina, Gertzen, Christoph G. W., Schäfle, Daniel, Zerbe, Katja, Gwerder, Myriam, Schnell, Simon D., Sander, Peter, Gohlke, Holger, Gademann, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734799/ https://www.ncbi.nlm.nih.gov/pubmed/33329763 http://dx.doi.org/10.1021/acsmedchemlett.0c00381

Ejemplares similares

Novel fidaxomicin antibiotics through site-selective catalysis
por: Dailler, David, et al.
Publicado: (2021)

Synthesis and characterization of semisynthetic analogs of the antifungal occidiofungin
por: Geng, Mengxin, et al.
Publicado: (2022)

In vitro activity of fidaxomicin and combinations of fidaxomicin with other antibiotics against Clostridium perfringens strains isolated from dogs and cats
por: Álvarez-Pérez, Sergio, et al.
Publicado: (2023)

Antimicrobial Activities of Fidaxomicin
por: Goldstein, Ellie J. C., et al.
Publicado: (2012)

Recent Advances in the Development of Semisynthetic Glycopeptide Antibiotics: 2014–2022
por: van Groesen, Emma, et al.
Publicado: (2022)

Structure-activity relationships in a series of semisynthetic polycyclic glycopeptide antibiotics
por: Olsuf’eva, E. N., et al.
Publicado: (2006)

Semisynthetic Approach toward Biologically Active Derivatives of Phenylspirodrimanes from S. chartarum
por: Steinert, Katharina, et al.
Publicado: (2022)

The secondary structure of the TGR5 membrane-proximal C-terminus determines plasma membrane localization and responsiveness towards extracellular ligands
por: Gertzen, Christoph, et al.
Publicado: (2014)

Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics
por: Balzarini, Jan, et al.
Publicado: (2006)

An Economic Analysis: Is Fidaxomicin Worth the Cost?
por: Shah, Hemal, et al.
Publicado: (2014)

Semisynthetic Pneumococcal Glycoconjugate Nanovaccine
por: Prasanna, Maruthi, et al.
Publicado: (2023)

Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus
por: Koteva, Kalinka, et al.
Publicado: (2023)

675. The Fidaxomicin Cascade: Analysis of Success Rates and Barriers of Fidaxomicin Discharge Prescriptions for Inpatients Diagnosed with Clostridiodes Difficile
por: Cook, Ellen, et al.
Publicado: (2023)

A Novel Polyester Hydrolase From the Marine Bacterium Pseudomonas aestusnigri – Structural and Functional Insights
por: Bollinger, Alexander, et al.
Publicado: (2020)

Safety Analysis of Fidaxomicin in Comparison With Oral Vancomycin for Clostridium difficile Infections
por: Weiss, Karl, et al.
Publicado: (2012)

Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections
por: Mullane, Kathleen M., et al.
Publicado: (2011)

Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis
por: Artsimovitch, Irina, et al.
Publicado: (2012)

Fidaxomicin Inhibits Spore Production in Clostridium difficile
por: Babakhani, Farah, et al.
Publicado: (2012)

Fidaxomicin - the new drug for Clostridium difficile infection
por: Vaishnavi, Chetana
Publicado: (2015)

Fidaxomicin Use in the Pediatric Population with Clostridioides difficile
por: Oliver, Meredith B, et al.
Publicado: (2022)

Semisynthetic roxburghin tetramethyl ether
por: Saez, Alex, et al.
Publicado: (2008)

Fidaxomicin versus Vancomycin in the Treatment of Clostridium difficile Infection: Canadian Outcomes
por: Lee, Christine, et al.
Publicado: (2016)

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus
por: Yuan, Jie, et al.
Publicado: (2020)

Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics
por: Shchelik, Inga S., et al.
Publicado: (2020)

Emerging therapies for Clostridium difficile infection – focus on fidaxomicin
por: Chaparro-Rojas, Fredy, et al.
Publicado: (2013)

Comparison of Fidaxomicin and Vancomycin for Recurrent Clostridium difficile Colitis
por: Khoo, Teresa, et al.
Publicado: (2017)

Biological Profiling of Semisynthetic C19-Functionalized Ferruginol and Sugiol Analogues
por: González-Cardenete, Miguel A., et al.
Publicado: (2021)

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach
por: Oueis, Emilia, et al.
Publicado: (2015)

Probing coenzyme A homeostasis with semisynthetic biosensors
por: Xue, Lin, et al.
Publicado: (2022)

High-precision FRET analysis of the G-protein coupled receptor TGR5 in live cells
por: Koch, Annemarie, et al.
Publicado: (2014)

Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection
por: Zhanel, George G, et al.
Publicado: (2015)

Fidaxomicin Use and Clinical Outcomes for Clostridium difficile–Associated Diarrhea
por: Eiland, Edward H., et al.
Publicado: (2015)

Proteomic Signatures of Clostridium difficile Stressed with Metronidazole, Vancomycin, or Fidaxomicin
por: Maaß, Sandra, et al.
Publicado: (2018)

Fidaxomicin as a Salvage Therapy for Fulminant Clostridioides difficile Infection
por: Heleno, Caio T, et al.
Publicado: (2021)

Exploitation of E. coli for the production of penicillin G amidase: a tool for the synthesis of semisynthetic β-lactam antibiotics
por: Sambyal, Krishika, et al.
Publicado: (2021)

Screening and Characterisation of Antimicrobial Properties of Semisynthetic Betulin Derivatives
por: Haque, Shafiul, et al.
Publicado: (2014)

Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry
por: Lee, Joongoo, et al.
Publicado: (2016)

Semisynthetic modifications of antitubercular lanostane triterpenoids from Ganoderma
por: Chinthanom, Panida, et al.
Publicado: (2021)

Amino Alcohols from Eugenol as Potential Semisynthetic Insecticides: Chemical, Biological, and Computational Insights
por: Pereira, Renato B., et al.
Publicado: (2021)

Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking
por: El-Kersh, Dina M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_19i1m76o54t8tv4sbghftil250