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Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks

Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a...

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Detalles Bibliográficos
Autores principales: Berkenbrock, José Alvim, Grecco-Machado, Rafaela, Achenbach, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735301/
https://www.ncbi.nlm.nih.gov/pubmed/33363440
http://dx.doi.org/10.1098/rspa.2020.0398
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author Berkenbrock, José Alvim
Grecco-Machado, Rafaela
Achenbach, Sven
author_facet Berkenbrock, José Alvim
Grecco-Machado, Rafaela
Achenbach, Sven
author_sort Berkenbrock, José Alvim
collection PubMed
description Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.
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spelling pubmed-77353012020-12-23 Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks Berkenbrock, José Alvim Grecco-Machado, Rafaela Achenbach, Sven Proc Math Phys Eng Sci Review Article Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity. The Royal Society Publishing 2020-11 2020-11-04 /pmc/articles/PMC7735301/ /pubmed/33363440 http://dx.doi.org/10.1098/rspa.2020.0398 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review Article
Berkenbrock, José Alvim
Grecco-Machado, Rafaela
Achenbach, Sven
Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title_full Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title_fullStr Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title_full_unstemmed Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title_short Microfluidic devices for the detection of viruses: aspects of emergency fabrication during the COVID-19 pandemic and other outbreaks
title_sort microfluidic devices for the detection of viruses: aspects of emergency fabrication during the covid-19 pandemic and other outbreaks
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735301/
https://www.ncbi.nlm.nih.gov/pubmed/33363440
http://dx.doi.org/10.1098/rspa.2020.0398
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