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The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling

Post myocardial infarction (MI) remodeling is the term used to define the changes in cardiac musculature after sustaining an ischemic injury. These changes decrease myocardial function and ultimately lead to heart failure. We review the contributing factors to post-MI remodeling, its association wit...

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Autores principales: Gutlapalli, Sai Dheeraj, Kondapaneni, Varshitha, Toulassi, Ijeoma A, Poudel, Sujan, Zeb, Mehwish, Choudhari, Jinal, Cancarevic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735524/
https://www.ncbi.nlm.nih.gov/pubmed/33329978
http://dx.doi.org/10.7759/cureus.11482
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author Gutlapalli, Sai Dheeraj
Kondapaneni, Varshitha
Toulassi, Ijeoma A
Poudel, Sujan
Zeb, Mehwish
Choudhari, Jinal
Cancarevic, Ivan
author_facet Gutlapalli, Sai Dheeraj
Kondapaneni, Varshitha
Toulassi, Ijeoma A
Poudel, Sujan
Zeb, Mehwish
Choudhari, Jinal
Cancarevic, Ivan
author_sort Gutlapalli, Sai Dheeraj
collection PubMed
description Post myocardial infarction (MI) remodeling is the term used to define the changes in cardiac musculature after sustaining an ischemic injury. These changes decrease myocardial function and ultimately lead to heart failure. We review the contributing factors to post-MI remodeling, its association with telomere biology, as well as a myriad of other factors affecting aging and telomere length in relation to cardiovascular health. The main focus is on the effects of resveratrol in the cardiovascular system and its potential for therapeutic use in preventing long-term cardiovascular morbidity and mortality. We tried to answer important questions regarding the potential for resveratrol as a therapeutic drug to prevent adverse post-MI remodeling. In our search, we gathered 62 studies and narrowed our data down to 44 studies. The database used was PubMed, and the keywords used are "Resveratrol", "Telomere", "Post Myocardial Infarction". All the studies were carefully screened for relevant articles regarding our topic manually, Articles related to a positive association between resveratrol and its anti-aging, cardioprotective effects have been included in our study, as we could not find any articles in our search which showed a negative correlation. Our review concluded that resveratrol had pro-telomerase effects which could counter the development of adverse post-MI remodeling. Therefore resveratrol could be a useful therapeutic add-on drug to prevent cardiovascular disease. It is essential that further research including observational and large-scale clinical trials should be conducted to increase our understanding of the efficacy and viability of these novel therapeutic interventions.
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spelling pubmed-77355242020-12-15 The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling Gutlapalli, Sai Dheeraj Kondapaneni, Varshitha Toulassi, Ijeoma A Poudel, Sujan Zeb, Mehwish Choudhari, Jinal Cancarevic, Ivan Cureus Cardiology Post myocardial infarction (MI) remodeling is the term used to define the changes in cardiac musculature after sustaining an ischemic injury. These changes decrease myocardial function and ultimately lead to heart failure. We review the contributing factors to post-MI remodeling, its association with telomere biology, as well as a myriad of other factors affecting aging and telomere length in relation to cardiovascular health. The main focus is on the effects of resveratrol in the cardiovascular system and its potential for therapeutic use in preventing long-term cardiovascular morbidity and mortality. We tried to answer important questions regarding the potential for resveratrol as a therapeutic drug to prevent adverse post-MI remodeling. In our search, we gathered 62 studies and narrowed our data down to 44 studies. The database used was PubMed, and the keywords used are "Resveratrol", "Telomere", "Post Myocardial Infarction". All the studies were carefully screened for relevant articles regarding our topic manually, Articles related to a positive association between resveratrol and its anti-aging, cardioprotective effects have been included in our study, as we could not find any articles in our search which showed a negative correlation. Our review concluded that resveratrol had pro-telomerase effects which could counter the development of adverse post-MI remodeling. Therefore resveratrol could be a useful therapeutic add-on drug to prevent cardiovascular disease. It is essential that further research including observational and large-scale clinical trials should be conducted to increase our understanding of the efficacy and viability of these novel therapeutic interventions. Cureus 2020-11-14 /pmc/articles/PMC7735524/ /pubmed/33329978 http://dx.doi.org/10.7759/cureus.11482 Text en Copyright © 2020, Gutlapalli et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Gutlapalli, Sai Dheeraj
Kondapaneni, Varshitha
Toulassi, Ijeoma A
Poudel, Sujan
Zeb, Mehwish
Choudhari, Jinal
Cancarevic, Ivan
The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title_full The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title_fullStr The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title_full_unstemmed The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title_short The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling
title_sort effects of resveratrol on telomeres and post myocardial infarction remodeling
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735524/
https://www.ncbi.nlm.nih.gov/pubmed/33329978
http://dx.doi.org/10.7759/cureus.11482
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