Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24

The integral membrane zinc metalloprotease ZMPSTE24 plays a key role in the proteolytic processing of farnesylated prelamin A, the precursor of the nuclear scaffold protein lamin A. Failure of this processing step results in the accumulation of permanently farnesylated forms of prelamin A which caus...

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Detalles Bibliográficos
Autores principales: Wood, Kaitlin M., Spear, Eric D., Mossberg, Otto W., Odinammadu, Kamsi O., Xu, Wenxin, Michaelis, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735620/
https://www.ncbi.nlm.nih.gov/pubmed/33315887
http://dx.doi.org/10.1371/journal.pone.0239269

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